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- W165224224 startingPage "39" @default.
- W165224224 abstract "Over the years, the role of the Wingless-int (Wnt) signaling pathway during embryogenesis has been the focus of many researchers, its role being fundamental for physiological organogenesis. More recently, during adulthood, the Wnt signaling pathway has been found to be involved in the regulation of a myriad of cellular processes, including cellular motility, proliferation, differentiation, survival, and apoptosis. It is therefore unsurprising that when this pathway becomes aberrant through anomalous regulation that cancer ensues. Indeed, this developmental pathway has been involved in cancers of the blood, thyroid, breast, lung, prostate, and colon. Key is the role that Wnt signaling plays in the regulation of stem cell fates, all within tightly regulated “niches.” Careful dissection of the various mechanisms controlling this pathway and the subsequent understanding of their functional significance during tissue homeostasis; how it affects stem cells and how it may contribute to carcinogenesis will result in new molecular-based disease markers and novel therapeutic agents to specifically target these diseases." @default.
- W165224224 created "2016-06-24" @default.
- W165224224 creator A5042932744 @default.
- W165224224 creator A5065705715 @default.
- W165224224 creator A5084397317 @default.
- W165224224 date "2009-01-01" @default.
- W165224224 modified "2023-09-27" @default.
- W165224224 title "Wnt Signaling in Cancer: From Embryogenesis to Stem Cell Self-Renewal" @default.
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