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- W1653214673 abstract "Neurotensin (NT) is a brain-gut tridecapeptide with putative hormonal and/or neurotransmitter functions in neural and extraneural tissues. The characteristics of [ 3 H]NT binding to rat brain synaptic membranes (neural receptor) and to the cell line HT 29 derived from a human colon carcinoma (extraneural receptors) were compared and found to be very similar. Both systems were used as radioreceptorassays for NT and a number of NT synthetic analogues. The binding affinities thus derived were in good agreement with the biological potencies of the peptides obtained from their ability to contract intestinal smooth muscle preparations. The structure-activity studies revealed the important role of the residues Arg 8 , Arg 9 , Tyr 11 , Ile 12 and the C-terminal residue Leu 13 for the interaction of NT with its receptors." @default.
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- W1653214673 date "1982-01-01" @default.
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- W1653214673 title "Neurotensin-Receptor Interactions: Binding and Pharmacological Studies; Biological Relevance; Structure-Activity Relationships" @default.
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- W1653214673 doi "https://doi.org/10.1016/b978-0-08-027988-6.50113-0" @default.
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