FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1653581937> ?p ?o ?g. }

• W1653581937 endingPage "662" @default.
• W1653581937 startingPage "659" @default.
• W1653581937 abstract "Intrathecal infusion of the neuropeptide FF analogue, [D-Tyr1, (NMe)Phe3]neuropeptide FF (1DMe; 0.1 microm-0.1 mm) in anaesthetized rats produced a concentration-dependent decrease in the spinal outflow of dynorphin A (1-8)-like material, which persisted for at least 90 min after treatment with 10 microm-0.1 mm of the compound. Co-administration of d-Phe-Cys-Tyr-D-Trp-Orn-Thr-Pen-Thr-NH2 (CTOP; 1 microm) to block spinal micro-opioid receptors did not modify this effect, whereas naltrindole (10 microm) totally prevented it and nor-binaltorphimine (10 microm) reduced the post-effect. These data suggest that 1DMe triggers the release of endogenous opioids that stimulate mainly delta-opioid receptors, and secondarily kappa-opioid receptors, thereby exerting a negative influence on dynorphin A (1-8)-like material outflow. Because dynorphin has pronociceptive properties, such a decrease in spinal dynorphin A (1-8)-like material release might underlie the long-lasting antinociceptive effects of intrathecally administered neuropeptide FF and analogues." @default.
• W1653581937 created "2016-06-24" @default.
• W1653581937 creator A5001240923 @default.
• W1653581937 creator A5001870458 @default.
• W1653581937 creator A5008454281 @default.
• W1653581937 creator A5009030222 @default.
• W1653581937 creator A5026942149 @default.
• W1653581937 creator A5038507730 @default.
• W1653581937 creator A5084440429 @default.
• W1653581937 date "2002-04-29" @default.
• W1653581937 modified "2023-10-18" @default.
• W1653581937 title "The neuropeptide FF analogue, 1DMe, reduces in vivo dynorphin release from the rat spinal cord" @default.
• W1653581937 cites W1867981554 @default.
• W1653581937 cites W1919059205 @default.
• W1653581937 cites W1973579311 @default.
• W1653581937 cites W1985773423 @default.
• W1653581937 cites W1986349967 @default.
• W1653581937 cites W2004266307 @default.
• W1653581937 cites W2011195852 @default.
• W1653581937 cites W2013213638 @default.
• W1653581937 cites W2022044685 @default.
• W1653581937 cites W2022766205 @default.
• W1653581937 cites W2028991114 @default.
• W1653581937 cites W2040964008 @default.
• W1653581937 cites W2052597998 @default.
• W1653581937 cites W2059470300 @default.
• W1653581937 cites W2066574371 @default.
• W1653581937 cites W2067182684 @default.
• W1653581937 cites W2085242913 @default.
• W1653581937 cites W2086937190 @default.
• W1653581937 cites W2093327340 @default.
• W1653581937 cites W2094043543 @default.
• W1653581937 cites W2170598964 @default.
• W1653581937 doi "https://doi.org/10.1046/j.1471-4159.2002.00914.x" @default.
• W1653581937 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12065675" @default.
• W1653581937 hasPublicationYear "2002" @default.
• W1653581937 type Work @default.
• W1653581937 sameAs 1653581937 @default.
• W1653581937 citedByCount "7" @default.
• W1653581937 countsByYear W16535819372015 @default.
• W1653581937 crossrefType "journal-article" @default.
• W1653581937 hasAuthorship W1653581937A5001240923 @default.
• W1653581937 hasAuthorship W1653581937A5001870458 @default.
• W1653581937 hasAuthorship W1653581937A5008454281 @default.
• W1653581937 hasAuthorship W1653581937A5009030222 @default.
• W1653581937 hasAuthorship W1653581937A5026942149 @default.
• W1653581937 hasAuthorship W1653581937A5038507730 @default.
• W1653581937 hasAuthorship W1653581937A5084440429 @default.
• W1653581937 hasBestOaLocation W16535819371 @default.
• W1653581937 hasConcept C118303440 @default.
• W1653581937 hasConcept C118552586 @default.
• W1653581937 hasConcept C126322002 @default.
• W1653581937 hasConcept C134018914 @default.
• W1653581937 hasConcept C151077648 @default.
• W1653581937 hasConcept C170493617 @default.
• W1653581937 hasConcept C184389661 @default.
• W1653581937 hasConcept C185592680 @default.
• W1653581937 hasConcept C2777953665 @default.
• W1653581937 hasConcept C2779886867 @default.
• W1653581937 hasConcept C2780775167 @default.
• W1653581937 hasConcept C2781063702 @default.
• W1653581937 hasConcept C2781181269 @default.
• W1653581937 hasConcept C71924100 @default.
• W1653581937 hasConcept C88016717 @default.
• W1653581937 hasConcept C93984277 @default.
• W1653581937 hasConcept C98274493 @default.
• W1653581937 hasConceptScore W1653581937C118303440 @default.
• W1653581937 hasConceptScore W1653581937C118552586 @default.
• W1653581937 hasConceptScore W1653581937C126322002 @default.
• W1653581937 hasConceptScore W1653581937C134018914 @default.
• W1653581937 hasConceptScore W1653581937C151077648 @default.
• W1653581937 hasConceptScore W1653581937C170493617 @default.
• W1653581937 hasConceptScore W1653581937C184389661 @default.
• W1653581937 hasConceptScore W1653581937C185592680 @default.
• W1653581937 hasConceptScore W1653581937C2777953665 @default.
• W1653581937 hasConceptScore W1653581937C2779886867 @default.
• W1653581937 hasConceptScore W1653581937C2780775167 @default.
• W1653581937 hasConceptScore W1653581937C2781063702 @default.
• W1653581937 hasConceptScore W1653581937C2781181269 @default.
• W1653581937 hasConceptScore W1653581937C71924100 @default.
• W1653581937 hasConceptScore W1653581937C88016717 @default.
• W1653581937 hasConceptScore W1653581937C93984277 @default.
• W1653581937 hasConceptScore W1653581937C98274493 @default.
• W1653581937 hasIssue "3" @default.
• W1653581937 hasLocation W16535819371 @default.
• W1653581937 hasLocation W16535819372 @default.
• W1653581937 hasOpenAccess W1653581937 @default.
• W1653581937 hasPrimaryLocation W16535819371 @default.
• W1653581937 hasRelatedWork W1433852924 @default.
• W1653581937 hasRelatedWork W1653581937 @default.
• W1653581937 hasRelatedWork W1970630470 @default.
• W1653581937 hasRelatedWork W1987852752 @default.
• W1653581937 hasRelatedWork W2020268600 @default.
• W1653581937 hasRelatedWork W2022358817 @default.
• W1653581937 hasRelatedWork W2054104931 @default.
• W1653581937 hasRelatedWork W2112537395 @default.
• W1653581937 hasRelatedWork W2471043327 @default.
• W1653581937 hasRelatedWork W2460053355 @default.

• next