Matches in SemOpenAlex for { <https://semopenalex.org/work/W1653736065> ?p ?o ?g. }
Showing items 1 to 53 of
53
with 100 items per page.
- W1653736065 endingPage "274" @default.
- W1653736065 startingPage "270" @default.
- W1653736065 abstract "The prevalence of atopic dermatitis has markedly increased in recent years but the mechanism has not been clearly revealed. Recent study exhibited that atopic dermatitis was exacerbated by the increase of proteinase-activated receptor (PAR)-2 expression, which activated IκB kinase --> nuclear factor kappa B. Therefore, we determined whether the allergens of dust mites induced the expression of PAR-2, intercellular adhesion molecule-1 (ICAM-1, adehision molecule), interleukins (IL)-6 in HaCaT keratocytes and which herbal 1,3-butylene glycol extracts (Mori Cortex Radicis, Sanguisorba officinalis L., Arctium lappa Linne, Torilis japonica DC, Melia azedarach Linne var. japoinca Makino) suppressed their expression. Dust mite allergen increased PAR-2, ICAM-1 and IL-6 expression in HaCaT cells in a dose-dependent manner up to 3 μg/mL but their expression reached the plateau over the dosages. The allergen (3 μg/mL) also secreted more cytokines such as tumor necrosis factor (TNF)-α and IL-6 into the media. Among five different herbal extracts (50 μg/mL), Mori Cortex Radicis and Sanguisorba officinalis L. suppressed the PAR-2, ICAM-1 and IL-6 expression in HaCaT cells, which was activated by dust mite allergen (3 μg/mL) and they also reduced the secretion of TNF-α and IL-6 into the media. In conclusion, Mori Cortex Radicis and Sanguisorba officinalis L. can effectively reduce the prevalence and progression of atopic dermatitis by dute mite allergen." @default.
- W1653736065 created "2016-06-24" @default.
- W1653736065 creator A5001675275 @default.
- W1653736065 creator A5083270484 @default.
- W1653736065 creator A5084896015 @default.
- W1653736065 date "2011-04-01" @default.
- W1653736065 modified "2023-09-22" @default.
- W1653736065 title "피부세포에서 아토피 피부염의 유발과 관련된 PAR-2 및 사이토카인의 발현을 감소시키는 한약재 탐색" @default.
- W1653736065 hasPublicationYear "2011" @default.
- W1653736065 type Work @default.
- W1653736065 sameAs 1653736065 @default.
- W1653736065 citedByCount "0" @default.
- W1653736065 crossrefType "journal-article" @default.
- W1653736065 hasAuthorship W1653736065A5001675275 @default.
- W1653736065 hasAuthorship W1653736065A5083270484 @default.
- W1653736065 hasAuthorship W1653736065A5084896015 @default.
- W1653736065 hasConcept C118995209 @default.
- W1653736065 hasConcept C153911025 @default.
- W1653736065 hasConcept C17991360 @default.
- W1653736065 hasConcept C185592680 @default.
- W1653736065 hasConcept C202751555 @default.
- W1653736065 hasConcept C203014093 @default.
- W1653736065 hasConcept C207480886 @default.
- W1653736065 hasConcept C2780510475 @default.
- W1653736065 hasConcept C55493867 @default.
- W1653736065 hasConcept C556039675 @default.
- W1653736065 hasConcept C71924100 @default.
- W1653736065 hasConcept C86803240 @default.
- W1653736065 hasConcept C98274493 @default.
- W1653736065 hasConceptScore W1653736065C118995209 @default.
- W1653736065 hasConceptScore W1653736065C153911025 @default.
- W1653736065 hasConceptScore W1653736065C17991360 @default.
- W1653736065 hasConceptScore W1653736065C185592680 @default.
- W1653736065 hasConceptScore W1653736065C202751555 @default.
- W1653736065 hasConceptScore W1653736065C203014093 @default.
- W1653736065 hasConceptScore W1653736065C207480886 @default.
- W1653736065 hasConceptScore W1653736065C2780510475 @default.
- W1653736065 hasConceptScore W1653736065C55493867 @default.
- W1653736065 hasConceptScore W1653736065C556039675 @default.
- W1653736065 hasConceptScore W1653736065C71924100 @default.
- W1653736065 hasConceptScore W1653736065C86803240 @default.
- W1653736065 hasConceptScore W1653736065C98274493 @default.
- W1653736065 hasIssue "2" @default.
- W1653736065 hasLocation W16537360651 @default.
- W1653736065 hasOpenAccess W1653736065 @default.
- W1653736065 hasPrimaryLocation W16537360651 @default.
- W1653736065 hasVolume "25" @default.
- W1653736065 isParatext "false" @default.
- W1653736065 isRetracted "false" @default.
- W1653736065 magId "1653736065" @default.
- W1653736065 workType "article" @default.