FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W165388538> ?p ?o ?g. }

• W165388538 endingPage "5037" @default.
• W165388538 startingPage "5037" @default.
• W165388538 abstract "To investigate the role of inflammatory and anti-viral genes in the pathogenesis of SARS.cDNA microarrays were used to screen the gene expression profiles of peripheral blood mononuclear cells (PBMCs) in two SARS patients (one in the acute severe phase and the other in the convalescent phase) and a healthy donor. In addition, real-time qualitative PCR was also performed to verify the reproducibility of the microarray results. The data were further analyzed.Many inflammatory and anti-viral genes were differentially expressed in SARS patients. Compared to the healthy control or the convalescent case, plenty of pro-inflammatory cytokines such as IL-1, TNF-alpha, IL-8, and MAPK signaling pathway were significantly upregulated in the acute severe case. However, anti-inflammatory agents such as IL-4 receptor, IL-13 receptor, IL-1Ra, and TNF-alpha-induced proteins 3 and 6 also increased dramatically in the acute severe case. On the contrary, a lot of IFN-stimulated genes like PKR, GBP-1 and 2, CXCL-10 and 11, and JAK/STAT signal pathway were downregulated in the acute severe case compared to the convalescent case.Gene expression in SARS patients mirrors a host state of inflammation and anti-viral immunity at the transcription level, and understanding of gene expression profiles may make contribution to further studies of the SARS pathogenesis." @default.
• W165388538 created "2016-06-24" @default.
• W165388538 creator A5013433245 @default.
• W165388538 creator A5019519148 @default.
• W165388538 creator A5046695487 @default.
• W165388538 creator A5077553497 @default.
• W165388538 creator A5081788512 @default.
• W165388538 creator A5084212623 @default.
• W165388538 date "2005-01-01" @default.
• W165388538 modified "2023-09-26" @default.
• W165388538 title "Gene expression profiles in peripheral blood mononuclear cells of SARS patients" @default.
• W165388538 cites W1495139852 @default.
• W165388538 cites W1504914687 @default.
• W165388538 cites W1543336029 @default.
• W165388538 cites W1545528913 @default.
• W165388538 cites W1977905350 @default.
• W165388538 cites W1990031758 @default.
• W165388538 cites W2000956978 @default.
• W165388538 cites W2024086482 @default.
• W165388538 cites W2045067890 @default.
• W165388538 cites W2046747192 @default.
• W165388538 cites W2056879548 @default.
• W165388538 cites W2070463916 @default.
• W165388538 cites W2078711199 @default.
• W165388538 cites W2084591292 @default.
• W165388538 cites W2085410427 @default.
• W165388538 cites W2107533095 @default.
• W165388538 cites W2112639947 @default.
• W165388538 cites W2116586125 @default.
• W165388538 cites W2119847512 @default.
• W165388538 cites W2120801007 @default.
• W165388538 cites W2124181672 @default.
• W165388538 cites W2130450914 @default.
• W165388538 cites W2149250436 @default.
• W165388538 cites W2158969445 @default.
• W165388538 cites W2160467108 @default.
• W165388538 cites W2167080692 @default.
• W165388538 cites W2169198329 @default.
• W165388538 cites W2170363109 @default.
• W165388538 cites W2172292246 @default.
• W165388538 cites W2620241325 @default.
• W165388538 doi "https://doi.org/10.3748/wjg.v11.i32.5037" @default.
• W165388538 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4321926" @default.
• W165388538 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16124062" @default.
• W165388538 hasPublicationYear "2005" @default.
• W165388538 type Work @default.
• W165388538 sameAs 165388538 @default.
• W165388538 citedByCount "47" @default.
• W165388538 countsByYear W1653885382013 @default.
• W165388538 countsByYear W1653885382015 @default.
• W165388538 countsByYear W1653885382017 @default.
• W165388538 countsByYear W1653885382018 @default.
• W165388538 countsByYear W1653885382019 @default.
• W165388538 countsByYear W1653885382020 @default.
• W165388538 countsByYear W1653885382021 @default.
• W165388538 countsByYear W1653885382022 @default.
• W165388538 countsByYear W1653885382023 @default.
• W165388538 crossrefType "journal-article" @default.
• W165388538 hasAuthorship W165388538A5013433245 @default.
• W165388538 hasAuthorship W165388538A5019519148 @default.
• W165388538 hasAuthorship W165388538A5046695487 @default.
• W165388538 hasAuthorship W165388538A5077553497 @default.
• W165388538 hasAuthorship W165388538A5081788512 @default.
• W165388538 hasAuthorship W165388538A5084212623 @default.
• W165388538 hasBestOaLocation W1653885381 @default.
• W165388538 hasConcept C104317684 @default.
• W165388538 hasConcept C137061746 @default.
• W165388538 hasConcept C150194340 @default.
• W165388538 hasConcept C17991360 @default.
• W165388538 hasConcept C18431079 @default.
• W165388538 hasConcept C186836561 @default.
• W165388538 hasConcept C202751555 @default.
• W165388538 hasConcept C203014093 @default.
• W165388538 hasConcept C2776239193 @default.
• W165388538 hasConcept C2776914184 @default.
• W165388538 hasConcept C2778277574 @default.
• W165388538 hasConcept C2778923194 @default.
• W165388538 hasConcept C2780942790 @default.
• W165388538 hasConcept C54355233 @default.
• W165388538 hasConcept C71924100 @default.
• W165388538 hasConcept C86803240 @default.
• W165388538 hasConceptScore W165388538C104317684 @default.
• W165388538 hasConceptScore W165388538C137061746 @default.
• W165388538 hasConceptScore W165388538C150194340 @default.
• W165388538 hasConceptScore W165388538C17991360 @default.
• W165388538 hasConceptScore W165388538C18431079 @default.
• W165388538 hasConceptScore W165388538C186836561 @default.
• W165388538 hasConceptScore W165388538C202751555 @default.
• W165388538 hasConceptScore W165388538C203014093 @default.
• W165388538 hasConceptScore W165388538C2776239193 @default.
• W165388538 hasConceptScore W165388538C2776914184 @default.
• W165388538 hasConceptScore W165388538C2778277574 @default.
• W165388538 hasConceptScore W165388538C2778923194 @default.
• W165388538 hasConceptScore W165388538C2780942790 @default.
• W165388538 hasConceptScore W165388538C54355233 @default.
• W165388538 hasConceptScore W165388538C71924100 @default.
• W165388538 hasConceptScore W165388538C86803240 @default.
• W165388538 hasIssue "32" @default.

• next