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- W1653965013 abstract "According to a study conducted in West Africa a genetic variation of hemoglobin the oxygen-carrying protein found in red blood cells (RBCs) can abolish the risk of falciparum malaria. However the gene variant called hemoglobin C may cause mild anemia and in some adults gallstones. Based on the findings which are published in the November 15 2001 issue of Nature magazine having two copies of hemoglobin C gene reduce the risk by 93% compared to the 73% risk reduction in people with normal hemoglobin gene paired with hemoglobin S gene and 67% protection by two copies of hemoglobin S. Hemoglobin S shields against malaria by distorting the RBCs into a sickle shape that is destroyed by the spleen along with the parasites it contains. However people with two copies of hemoglobin S gene often develop potentially lethal sickle- cell anemia. Lastly the researchers are currently conducting a study in Burkina Faso to find out whether hemoglobin C merely controls the disease or if it totally blocks the infection." @default.
- W1653965013 created "2016-06-24" @default.
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- W1653965013 date "2002-01-01" @default.
- W1653965013 modified "2023-09-23" @default.
- W1653965013 title "Haemoglobin variant gives strong protection against malaria." @default.
- W1653965013 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2567636" @default.
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