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- W165428382 abstract "Parachlorophenylalanine (PCPA) depletes serotonin (5-HT) in brain, pineal, and other tissue by inhibition or inactivation of tryptophan hydroxylase. PCPA inactivates tryptophan hydroxylase in rat brain in vivo , whereas PCPA is a competitive inhibitor of tryptophan hydroxylase in vitro . PCPA does not inactivate tryptophan hydroxylase in rat pineal. This chapter presents a report that showed that PCPA does not inactivate tryptophan hydroxylase in rat pineal. The results indicated that the biochemical effect of PCPA is different between pineal and cerebral hydroxylase and that tryptophan hydroxylase in rat pineal may be a different enzyme from that in rat brain. PCPA also blocks the conversion of a tracer dose of tryptophan to 5-HT. If the enzyme molecules of tryptophan hydroxylase are different between pineal and brain of rats, the regulation of tryptophan hydroxylase might be different between these two tissues." @default.
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- W165428382 date "1973-01-01" @default.
- W165428382 modified "2023-09-26" @default.
- W165428382 title "COMPARATIVE STUDIES ON THE EFFECT OF PARACHLOROPHENYLALANINE ON HYDROXYLATION OF TRYPTOPHAN IN PINEAL AND BRAIN OF RAT" @default.
- W165428382 doi "https://doi.org/10.1016/b978-0-12-078150-8.50012-8" @default.
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