Matches in SemOpenAlex for { <https://semopenalex.org/work/W165439428> ?p ?o ?g. }
- W165439428 endingPage "290" @default.
- W165439428 startingPage "273" @default.
- W165439428 abstract "Mammalian pancreatic-type ribonucleases (ptRNases) comprise an enzyme family that is remarkably well suited for therapeutic exploitation. ptRNases are robust and prodigious catalysts of RNA cleavage that can naturally access the cytosol. Instilling cytotoxic activity requires endowing them with the ability to evade a cytosolic inhibitor protein while retaining other key attributes. These efforts have informed our understanding of ptRNase-based cytotoxins, as well as the action of protein-based drugs with cytosolic targets. Here, we address the most pressing problems encountered in the design of cytotoxic ptRNases, along with potential solutions. In addition, we describe assays that can be used to evaluate a successful design in vitro, in cellulo, and in vivo. The emerging information validates the continuing development of ptRNases as chemotherapeutic agents." @default.
- W165439428 created "2016-06-24" @default.
- W165439428 creator A5019213891 @default.
- W165439428 creator A5019810473 @default.
- W165439428 creator A5079897277 @default.
- W165439428 date "2012-01-01" @default.
- W165439428 modified "2023-10-16" @default.
- W165439428 title "Rational Design and Evaluation of Mammalian Ribonuclease Cytotoxins" @default.
- W165439428 cites W1552732056 @default.
- W165439428 cites W1562498268 @default.
- W165439428 cites W178521243 @default.
- W165439428 cites W1964580362 @default.
- W165439428 cites W1966547604 @default.
- W165439428 cites W1969010591 @default.
- W165439428 cites W1974601454 @default.
- W165439428 cites W1976789622 @default.
- W165439428 cites W1985139909 @default.
- W165439428 cites W1987797744 @default.
- W165439428 cites W1991269320 @default.
- W165439428 cites W1991978633 @default.
- W165439428 cites W1995697509 @default.
- W165439428 cites W1998307511 @default.
- W165439428 cites W1998745985 @default.
- W165439428 cites W2011831437 @default.
- W165439428 cites W2015221912 @default.
- W165439428 cites W2021975670 @default.
- W165439428 cites W2022563903 @default.
- W165439428 cites W2025084140 @default.
- W165439428 cites W2025629542 @default.
- W165439428 cites W2026895880 @default.
- W165439428 cites W2027561183 @default.
- W165439428 cites W2029716029 @default.
- W165439428 cites W2030836217 @default.
- W165439428 cites W2033337714 @default.
- W165439428 cites W2036911034 @default.
- W165439428 cites W2039670099 @default.
- W165439428 cites W2044592471 @default.
- W165439428 cites W2047505435 @default.
- W165439428 cites W2053135718 @default.
- W165439428 cites W2054387236 @default.
- W165439428 cites W2057877973 @default.
- W165439428 cites W2062866138 @default.
- W165439428 cites W2071319158 @default.
- W165439428 cites W2073130207 @default.
- W165439428 cites W2074110704 @default.
- W165439428 cites W2078036275 @default.
- W165439428 cites W2086256540 @default.
- W165439428 cites W2086928290 @default.
- W165439428 cites W2088304746 @default.
- W165439428 cites W2089717292 @default.
- W165439428 cites W2094657119 @default.
- W165439428 cites W2108627855 @default.
- W165439428 cites W2150360629 @default.
- W165439428 cites W2151827208 @default.
- W165439428 cites W2158649428 @default.
- W165439428 cites W2175408680 @default.
- W165439428 cites W4211216439 @default.
- W165439428 cites W2024940032 @default.
- W165439428 doi "https://doi.org/10.1016/b978-0-12-416039-2.00014-8" @default.
- W165439428 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3304445" @default.
- W165439428 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22208989" @default.
- W165439428 hasPublicationYear "2012" @default.
- W165439428 type Work @default.
- W165439428 sameAs 165439428 @default.
- W165439428 citedByCount "30" @default.
- W165439428 countsByYear W1654394282012 @default.
- W165439428 countsByYear W1654394282013 @default.
- W165439428 countsByYear W1654394282014 @default.
- W165439428 countsByYear W1654394282015 @default.
- W165439428 countsByYear W1654394282016 @default.
- W165439428 countsByYear W1654394282017 @default.
- W165439428 countsByYear W1654394282018 @default.
- W165439428 countsByYear W1654394282019 @default.
- W165439428 countsByYear W1654394282020 @default.
- W165439428 countsByYear W1654394282021 @default.
- W165439428 countsByYear W1654394282022 @default.
- W165439428 crossrefType "book-chapter" @default.
- W165439428 hasAuthorship W165439428A5019213891 @default.
- W165439428 hasAuthorship W165439428A5019810473 @default.
- W165439428 hasAuthorship W165439428A5079897277 @default.
- W165439428 hasBestOaLocation W1654394282 @default.
- W165439428 hasConcept C104317684 @default.
- W165439428 hasConcept C10879258 @default.
- W165439428 hasConcept C109316439 @default.
- W165439428 hasConcept C154317977 @default.
- W165439428 hasConcept C181199279 @default.
- W165439428 hasConcept C185592680 @default.
- W165439428 hasConcept C202751555 @default.
- W165439428 hasConcept C2778976237 @default.
- W165439428 hasConcept C53105671 @default.
- W165439428 hasConcept C54355233 @default.
- W165439428 hasConcept C55493867 @default.
- W165439428 hasConcept C67705224 @default.
- W165439428 hasConcept C70721500 @default.
- W165439428 hasConcept C86803240 @default.
- W165439428 hasConcept C98539663 @default.
- W165439428 hasConceptScore W165439428C104317684 @default.
- W165439428 hasConceptScore W165439428C10879258 @default.