FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1654440160> ?p ?o ?g. }

• W1654440160 endingPage "192" @default.
• W1654440160 startingPage "187" @default.
• W1654440160 abstract "The axonal microtubule stabilizing protein tau is hyperphosphorylated in several neurodegenerative conditions, including Alzheimer's disease, yet the genes that regulate tau phosphorylation are largely unknown. Disabled-1 (Dab1) is a cytoplasmic adapter protein that interacts with apolipoprotein E (ApoE) receptors and controls neuronal positioning during embryonic brain development. We have investigated the role of Dab1 in tau phosphorylation. We found that wild-type Dab1, but not a mutant lacking tyrosine phosphorylation sites, protects mice from the hyperphosphorylation of tau. However, the absence of Dab1 is not sufficient to cause tau hyperphosphorylation, because hyperphosphorylation is manifested only when Dab1 is mutated in specific mouse strain backgrounds. Tau hyperphosphorylation correlates with early death in susceptible mouse strains, and it occurs in the neurons of the hippocampus and dentate gyrus. By quantitative trait locus (QTL) analysis of Dab1-deficient mice on a hybrid strain background, we uncovered one significant and three suggestive chromosomal loci that modulate tau phosphorylation. Two of these QTL regions contain genes that are defective in early onset Alzheimer's disease. Our findings suggest that Dab1 gene disruption sensitizes mice to tau hyperphosphorylation contingent on specific haplotypes that are linked to Alzheimer's disease loci. Dab1 mutant mice provide an animal model for studying the relationships between ApoE receptors, tau hyperphosphorylation, and Alzheimer's disease." @default.
• W1654440160 created "2016-06-24" @default.
• W1654440160 creator A5011885676 @default.
• W1654440160 creator A5012821611 @default.
• W1654440160 creator A5018773311 @default.
• W1654440160 creator A5023127754 @default.
• W1654440160 creator A5033347099 @default.
• W1654440160 creator A5037865809 @default.
• W1654440160 creator A5038529785 @default.
• W1654440160 creator A5054516987 @default.
• W1654440160 creator A5072832150 @default.
• W1654440160 creator A5076158761 @default.
• W1654440160 creator A5090461878 @default.
• W1654440160 date "2003-01-01" @default.
• W1654440160 modified "2023-10-16" @default.
• W1654440160 title "Genetic Modulation of Tau Phosphorylation in the Mouse" @default.
• W1654440160 cites W1480786153 @default.
• W1654440160 cites W1482580692 @default.
• W1654440160 cites W1667992367 @default.
• W1654440160 cites W1821101374 @default.
• W1654440160 cites W1958842451 @default.
• W1654440160 cites W1965232330 @default.
• W1654440160 cites W1966161684 @default.
• W1654440160 cites W1966614543 @default.
• W1654440160 cites W1967321689 @default.
• W1654440160 cites W1970020239 @default.
• W1654440160 cites W1976741643 @default.
• W1654440160 cites W1979890518 @default.
• W1654440160 cites W1981023728 @default.
• W1654440160 cites W1983795337 @default.
• W1654440160 cites W1994030229 @default.
• W1654440160 cites W1998129710 @default.
• W1654440160 cites W2001688761 @default.
• W1654440160 cites W2015171213 @default.
• W1654440160 cites W2022840078 @default.
• W1654440160 cites W2033822739 @default.
• W1654440160 cites W2041229701 @default.
• W1654440160 cites W2051540057 @default.
• W1654440160 cites W2053063666 @default.
• W1654440160 cites W2056338790 @default.
• W1654440160 cites W2060924536 @default.
• W1654440160 cites W2070651871 @default.
• W1654440160 cites W2070971554 @default.
• W1654440160 cites W2077464099 @default.
• W1654440160 cites W2080893376 @default.
• W1654440160 cites W2082429191 @default.
• W1654440160 cites W2082942943 @default.
• W1654440160 cites W2090547876 @default.
• W1654440160 cites W2091798758 @default.
• W1654440160 cites W2096386031 @default.
• W1654440160 cites W2105704879 @default.
• W1654440160 cites W2110888808 @default.
• W1654440160 cites W2113438288 @default.
• W1654440160 cites W2114056141 @default.
• W1654440160 cites W2120072717 @default.
• W1654440160 cites W2122230892 @default.
• W1654440160 cites W2148066913 @default.
• W1654440160 cites W2149945426 @default.
• W1654440160 cites W2159643400 @default.
• W1654440160 cites W2162321314 @default.
• W1654440160 cites W2163864270 @default.
• W1654440160 cites W2164037479 @default.
• W1654440160 cites W2166155593 @default.
• W1654440160 cites W2167350182 @default.
• W1654440160 cites W2317230108 @default.
• W1654440160 cites W47608607 @default.
• W1654440160 doi "https://doi.org/10.1523/jneurosci.23-01-00187.2003" @default.
• W1654440160 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6742161" @default.
• W1654440160 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12514215" @default.
• W1654440160 hasPublicationYear "2003" @default.
• W1654440160 type Work @default.
• W1654440160 sameAs 1654440160 @default.
• W1654440160 citedByCount "79" @default.
• W1654440160 countsByYear W16544401602012 @default.
• W1654440160 countsByYear W16544401602013 @default.
• W1654440160 countsByYear W16544401602014 @default.
• W1654440160 countsByYear W16544401602015 @default.
• W1654440160 countsByYear W16544401602016 @default.
• W1654440160 countsByYear W16544401602019 @default.
• W1654440160 countsByYear W16544401602020 @default.
• W1654440160 countsByYear W16544401602021 @default.
• W1654440160 countsByYear W16544401602022 @default.
• W1654440160 countsByYear W16544401602023 @default.
• W1654440160 crossrefType "journal-article" @default.
• W1654440160 hasAuthorship W1654440160A5011885676 @default.
• W1654440160 hasAuthorship W1654440160A5012821611 @default.
• W1654440160 hasAuthorship W1654440160A5018773311 @default.
• W1654440160 hasAuthorship W1654440160A5023127754 @default.
• W1654440160 hasAuthorship W1654440160A5033347099 @default.
• W1654440160 hasAuthorship W1654440160A5037865809 @default.
• W1654440160 hasAuthorship W1654440160A5038529785 @default.
• W1654440160 hasAuthorship W1654440160A5054516987 @default.
• W1654440160 hasAuthorship W1654440160A5072832150 @default.
• W1654440160 hasAuthorship W1654440160A5076158761 @default.
• W1654440160 hasAuthorship W1654440160A5090461878 @default.
• W1654440160 hasBestOaLocation W16544401601 @default.
• W1654440160 hasConcept C104317684 @default.
• W1654440160 hasConcept C11960822 @default.

• next