Matches in SemOpenAlex for { <https://semopenalex.org/work/W1655135214> ?p ?o ?g. }
Showing items 1 to 76 of
76
with 100 items per page.
- W1655135214 endingPage "200.18" @default.
- W1655135214 startingPage "200.18" @default.
- W1655135214 abstract "Abstract Autoreactive CD4 T cells are key effectors in Systemic Lupus Erythematosus (SLE). Cell metabolism is an important checkpoint for T cell activation, proliferation, and differentiation. We hypothesized that 1) SLE T cells have metabolic defects that cause abnormal T cell functions; 2) Targeting T cell metabolism may abrogate T cell inflammatory functions and reduce disease symptoms in SLE mice. Metabolism of CD4 T cells from lupus-resistant B6 mice and the congenic lupus model B6.Sle1.Sle2.Sle3 (B6.TC) were studied. Here it was observed that compared to B6, CD4 T cells from B6.TC mice have a stronger glycolysis and a higher mitochondrial oxygen consumption, as well as an enhanced mTOR activity. To normalize T cell metabolism in B6.TC mice, we used metformin, which activates the AMPK pathway and inhibits mitochondrial oxygen consumption, and 2-DG, an inhibitor of glycolysis. In vitro, metformin blocks IFNγ production by CD4 T cells and facilitates Treg development. 2-DG also blocks IFNγ production, but only after T cell activation. In vivo, a combined treatment with metformin and 2-DG of B6.TC mice normalized T cell metabolism and reversed disease phenotypes, including T cell activation and autoantibody production. Further, CD4 T cells from SLE patients have an enhanced metabolism as compared to healthy controls, and excessive IFNγ production was significantly reduced by metformin. Our research suggests that T cell metabolism is a novel target for SLE treatment." @default.
- W1655135214 created "2016-06-24" @default.
- W1655135214 creator A5000279531 @default.
- W1655135214 creator A5002019326 @default.
- W1655135214 creator A5022970292 @default.
- W1655135214 creator A5027375274 @default.
- W1655135214 creator A5046845352 @default.
- W1655135214 creator A5076723404 @default.
- W1655135214 creator A5080672026 @default.
- W1655135214 date "2014-05-01" @default.
- W1655135214 modified "2023-09-27" @default.
- W1655135214 title "Metabolic inhibitors normalize CD4 T cell metabolism and functions, and reverse disease in a murine model of lupus (THER5P.839)" @default.
- W1655135214 doi "https://doi.org/10.4049/jimmunol.192.supp.200.18" @default.
- W1655135214 hasPublicationYear "2014" @default.
- W1655135214 type Work @default.
- W1655135214 sameAs 1655135214 @default.
- W1655135214 citedByCount "0" @default.
- W1655135214 crossrefType "journal-article" @default.
- W1655135214 hasAuthorship W1655135214A5000279531 @default.
- W1655135214 hasAuthorship W1655135214A5002019326 @default.
- W1655135214 hasAuthorship W1655135214A5022970292 @default.
- W1655135214 hasAuthorship W1655135214A5027375274 @default.
- W1655135214 hasAuthorship W1655135214A5046845352 @default.
- W1655135214 hasAuthorship W1655135214A5076723404 @default.
- W1655135214 hasAuthorship W1655135214A5080672026 @default.
- W1655135214 hasConcept C126322002 @default.
- W1655135214 hasConcept C134018914 @default.
- W1655135214 hasConcept C203014093 @default.
- W1655135214 hasConcept C2776090121 @default.
- W1655135214 hasConcept C2776912625 @default.
- W1655135214 hasConcept C2779134260 @default.
- W1655135214 hasConcept C2779306644 @default.
- W1655135214 hasConcept C2780323712 @default.
- W1655135214 hasConcept C502942594 @default.
- W1655135214 hasConcept C55493867 @default.
- W1655135214 hasConcept C62112901 @default.
- W1655135214 hasConcept C71924100 @default.
- W1655135214 hasConcept C86803240 @default.
- W1655135214 hasConcept C8891405 @default.
- W1655135214 hasConcept C95444343 @default.
- W1655135214 hasConceptScore W1655135214C126322002 @default.
- W1655135214 hasConceptScore W1655135214C134018914 @default.
- W1655135214 hasConceptScore W1655135214C203014093 @default.
- W1655135214 hasConceptScore W1655135214C2776090121 @default.
- W1655135214 hasConceptScore W1655135214C2776912625 @default.
- W1655135214 hasConceptScore W1655135214C2779134260 @default.
- W1655135214 hasConceptScore W1655135214C2779306644 @default.
- W1655135214 hasConceptScore W1655135214C2780323712 @default.
- W1655135214 hasConceptScore W1655135214C502942594 @default.
- W1655135214 hasConceptScore W1655135214C55493867 @default.
- W1655135214 hasConceptScore W1655135214C62112901 @default.
- W1655135214 hasConceptScore W1655135214C71924100 @default.
- W1655135214 hasConceptScore W1655135214C86803240 @default.
- W1655135214 hasConceptScore W1655135214C8891405 @default.
- W1655135214 hasConceptScore W1655135214C95444343 @default.
- W1655135214 hasIssue "1_Supplement" @default.
- W1655135214 hasLocation W16551352141 @default.
- W1655135214 hasOpenAccess W1655135214 @default.
- W1655135214 hasPrimaryLocation W16551352141 @default.
- W1655135214 hasRelatedWork W2005084305 @default.
- W1655135214 hasRelatedWork W2012578977 @default.
- W1655135214 hasRelatedWork W2016264464 @default.
- W1655135214 hasRelatedWork W2033313326 @default.
- W1655135214 hasRelatedWork W2037520541 @default.
- W1655135214 hasRelatedWork W2072752555 @default.
- W1655135214 hasRelatedWork W2107068945 @default.
- W1655135214 hasRelatedWork W2411678126 @default.
- W1655135214 hasRelatedWork W2744240433 @default.
- W1655135214 hasRelatedWork W3087419739 @default.
- W1655135214 hasVolume "192" @default.
- W1655135214 isParatext "false" @default.
- W1655135214 isRetracted "false" @default.
- W1655135214 magId "1655135214" @default.
- W1655135214 workType "article" @default.