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- W1655364064 abstract "Summary Hypericum perforatum is a vegetal compound commonly known as St. John’s wort. For decades, it was used in traditional medicine as an astringent, antiseptic and pro-scarring agent externally, and as a treatment for sleep disturbances and depression when orally administered. This plant’s mechanism of action is not absolutely clear, but it is seemingly associated with the presence of hypericin, a naphtodianthro ne, in its composition. Clinical trials comparing St. John’s wort effectiveness versus placebo and standard antidepressants in the treatment of mild-to-moderate depression have yielded superior results in the first case, and similar results in the second case. The number of clinical trials, however, is still scarce, and effectiveness extent cannot be definitively concluded. It is well tolerated when administered, and most common adverse reactions are gastrointestinal disturbances, fatigue, confusion and sedation. The use of this medicinal plant is absolutely contraindicated during pregnancy, because of its abortive properties. On the other hand, the activity of hyperacin and pseudohyperacin ‐ and of flavonoids included in Hypericum perforatum ‐ as inductors of liver enzymes such as CYP1A2 and glutation-Stransferase may stimulate CYP3A4 and glycoprotein P, and may thus interfere with drugs using the CYP1A2, CYP3A4, glutationS-transferase and glycoprotein P metabolic routes. Blood concen trations of such drugs would be decreased, and it is thus necessary that concomitant drug use be closely monitored. The recommended daily dose for an adult with mild-to-moderate depression is 0.9 to 2.7 mg hyperacin, which is equivalent to 300-900 mg of Hypericum perforatum extract." @default.
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- W1655364064 date "2001-11-01" @default.
- W1655364064 modified "2023-09-28" @default.
- W1655364064 title "Hierba de San Juan (Hypericum perforatum sp)" @default.
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