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- W1655761211 abstract "This chapter describes the parallel inhibitions by 4-pentenoic acid of fatty acid oxidation and the two thiolases present in rat heart mitochondria. Experiments with purified 3-ketoacyl-CoA thiolase demonstrate that this enzyme is most rapidly inactivated by 3-keto-4-pentenoyl-CoA, a possible metabolite of 4-pentenoic acid. Rates of respiration supported by one of several substrates are then measured. Substrates used, their concentrations, and the rates of respiration observed in the absence of either n-pentanoate or 4-pentenoate are presented. Both acetoacetyl-CoA thiolase and 3-ketoacyl-CoA thiolase are inhibited to the same extent and at equal rates, which parallel initially the decrease in palmitoylcarnitine-supported respiration, n-pentanoate in contrast to 4-pentenoate is noninhibitory. Respiration supported by either octanoate or palmitoyl-CoA is inhibited by 4-pentenoate in a manner similar to that observed with palmitoylcarnitine as a substrate. The pyruvate-supported respiration is only slightly inhibited by both n-pentanoate and 4-pentenoate. It is suggested that the main cause for the inhibition of fatty acid oxidation by 4-pentenoate as reflected by the decreased respiratory rate is possibly the irreversible inactivation of 3-ketoacyl-CoA thiolase." @default.
- W1655761211 created "2016-06-24" @default.
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- W1655761211 date "1981-01-01" @default.
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- W1655761211 title "[48] 4-Pentenoic acid" @default.
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- W1655761211 doi "https://doi.org/10.1016/s0076-6879(81)72050-0" @default.
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