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- W165587306 abstract "6-Hydroxydopamine (6-OHDA), a potent neurotoxin that causes the degeneration of dopaminergic neurons, has been widely used for producing in vitro and in vivo Parkinsonian model. In the present study, we investigated the protective effects and the molecular action mechanism of fustin, a flavonoid derived from Rhus verniciflua Stokes (RVS), on 6-OHDA-treated SK-N-SH human neuroblastoma cells. We found that 6-OHDA-induced apoptotic cell death was mediated through ROS generation, phosphorylation of extracellular signal-regulated kinase 1/2 (ERK1/2), alteration of Bax/Bcl-2 ratio and caspase-3 activation in the cells. However, pretreatment with fustin scavenged ROS generated by 6-OHDA. Furthermore, fustin blocked the 6-OHDA-induced caspase-3 activity. These results suggest that fustin may protect the 6-OHDA-induced neuronal cell death possibly through free radical scavenging activity, and subsequent inhibition of caspase-3 activation. Consequently, we suggest that fustin may be a valuable compound for the protection from the Parkinson's disease." @default.
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- W165587306 date "2006-03-01" @default.
- W165587306 modified "2023-09-27" @default.
- W165587306 title "Protective Effects of Fustin, a flavonoid from Rhus verniciflua Stokes, on 6‐hydroxydopamine‐induced neurotoxicity in SK‐N‐SH cells" @default.
- W165587306 doi "https://doi.org/10.1096/fasebj.20.5.a1132-b" @default.
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