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- W1656163606 abstract "MP-III-024 is a benzodiazepine (BZ) analog that, based on pharmacophore modeling, is predicted to exhibit agonist activity at the BZ site on the GABA-A receptor. The present study assessed the behavioral effects of MP-III-024 on four endpoints in C57BL/6 mice. First, the antihyperalgesic effects of MP-III-024 were assessed in a model of inflammatory pain. Here, mechanical sensitivity was assessed following subcutaneous injection of the yeast extract zymosan A into the plantar surface of the footpad. MP-III-024 (1 – 32 mg/kg) produced dose- and time-dependent reversal of mechanical sensitivity on this endpoint. Second, the anxiolytic-like effects of MP-III-024 were assessed in a Vogel conflict procedure. In this procedure, MP-III-024 produced dose-dependent increases in rates of suppressed responding up to a dose of 32 mg/kg, and decreases in responding below vehicle levels were observed at 100 mg/kg. Next, ambulatory behavior was assessed in locomotor activity chambers. In this procedure, MP-III-024 (1 – 32 mg/kg) failed to produce effects that were significantly different from vehicle. Finally, the response rate-decreasing effects of MP-III-024 were examined in an assay of schedule controlled responding. Across the dose range tested, MP-III-024 (10-100 mg/kg) failed to alter response rates in this procedure. Together, these observations will help provide a framework for studying GABA-A receptor pharmacology which in turn should help guide the development of improved therapeutic agents for the treatment of pain- and anxiety-related disorders." @default.
- W1656163606 created "2016-06-24" @default.
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- W1656163606 date "2015-04-01" @default.
- W1656163606 modified "2023-09-27" @default.
- W1656163606 title "Behavioral effects of the novel benzodiazepine analog methyl 8‐ethynyl‐6‐(pyridin‐2‐yl)‐4H‐benzo[f]imidazo[1,5‐a][1,4]diazepine‐3‐carboxylate (MP‐III‐024)" @default.
- W1656163606 doi "https://doi.org/10.1096/fasebj.29.1_supplement.616.13" @default.
- W1656163606 hasPublicationYear "2015" @default.
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