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- W1656193908 abstract "Estradiol rapidly modulates hippocampal synaptic plasticity and synaptic transmission; however, the contribution of the various estrogen receptors to rapid changes in synaptic function is unclear. This study examined the effect of estrogen receptor selective agonists on hippocampal synaptic transmission in slices obtained from 3-5-month-old wild type (WT), estrogen receptor alpha (ERαKO), and beta (ERβKO) knockout female ovariectomized mice. Hippocampal slices were prepared 10-16 days following ovariectomy and extracellular excitatory postsynaptic field potentials were recorded from CA3-CA1 synaptic contacts before and following application of 17β-estradiol-3-benzoate (EB, 100 pM), the G-protein estrogen receptor 1 (GPER1) agonist G1 (100 nM), the ERα selective agonist propyl pyrazole triol (PPT, 100 nM), or the ERβ selective agonist diarylpropionitrile (DPN, 1 µM). Across all groups, EB and G1 increased the synaptic response to a similar extent. Furthermore, prior G1 application occluded the EB-mediated enhancement of the synaptic response and the GPER1 antagonist, G15 (100 nM), inhibited the enhancement of the synaptic response induced by EB application. We confirmed that the ERα and ERβ selective agonists (PPT and DPN) had effects on synaptic responses specific to animals that expressed the relevant receptor; however, PPT and DPN produced only a small increase in synaptic transmission relative to EB or the GPER1 agonist. We demonstrate that the increase in synaptic transmission is blocked by inhibition of extracellular signal-regulated kinase (ERK) activity. Furthermore, EB was able to increase ERK activity regardless of genotype. These results suggest that ERK activation and enhancement of synaptic transmission by EB involves multiple estrogen receptor subtypes." @default.
- W1656193908 created "2016-06-24" @default.
- W1656193908 creator A5029037756 @default.
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- W1656193908 creator A5060997323 @default.
- W1656193908 creator A5076924297 @default.
- W1656193908 creator A5082633730 @default.
- W1656193908 date "2015-06-12" @default.
- W1656193908 modified "2023-10-17" @default.
- W1656193908 title "Contribution of estrogen receptor subtypes, ERα, ERβ, and GPER1 in rapid estradiol-mediated enhancement of hippocampal synaptic transmission in mice" @default.
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- W1656193908 doi "https://doi.org/10.1002/hipo.22475" @default.
- W1656193908 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4644731" @default.
- W1656193908 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25980457" @default.
- W1656193908 hasPublicationYear "2015" @default.
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