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• W1656281284 abstract "This chapter examines the synthesis and clinical studies of antianginal agents. Angina pectoris is a painful symptom of myocardial ischemia occurring when the oxygen supply cannot meet the requirements of the heart. Nitroglycerin is the oldest and most effective antianginal agent in use. Used prophylactically or for immediate relief of anginal pain, nitroglycerin acts by reducing heart work and by redistributing blood flow to the ischemic areas of the myocardium. The beneficial effect of nitroglycerin on the myocardial circulation of dogs is the result of a number of actions. In contrast to nitroglycerin and pentaerythritol tetranitrate coronary vasodilators such as dipyridamole and chromonar increased total coronary blood flow in dogs without redistributing blood flow or improving endocardial oxygen tension. Adenosine uptake may involve a membrane-bound kinase enzyme which releases adenosine as its monophosphate within the cell. Dipyridamole inhibits this membranal kinase in guinea pigs to a greater degree than soluble intracellular adenosine deaminase or kinase enzymes." @default.
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• W1656281284 date "1972-01-01" @default.
• W1656281284 modified "2023-09-25" @default.
• W1656281284 title "Chapter 7. Antianginal Agents" @default.
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• W1656281284 doi "https://doi.org/10.1016/s0065-7743(08)60802-7" @default.
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