FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1656556746> ?p ?o ?g. }

• W1656556746 endingPage "1717" @default.
• W1656556746 startingPage "1708" @default.
• W1656556746 abstract "Management of oral leukoplakia—a potentially malignant disorder—is currently not evidence-based. Of the few randomized trials that have been reported, most have negative data. Therefore, a multi-centre, randomized, double-blind controlled trial (RCT) was undertaken to evaluate the use of low-dose beta-carotene combined with vitamin C supplements for the treatment and to prevent malignant transformation of oral leukoplakia. 46 Japanese participants with oral leukoplakia were allocated randomly either to an experimental arm (10 mg day−1 of beta-carotene and 500 mg day−1 of vitamin C) or placebo arm (50 mg day−1 of vitamin C). Current or ex-smokers within 3 months of cessation were excluded. The supplements were continued over a period of 1 year. The primary endpoint was clinical remission at 1-year and the likelihood of malignant transformation during a 5-year follow-up period as a secondary endpoint. The overall clinical response rate in the experimental arm was 17.4% (4/23) and 4.3% (1/23) in the placebo arm (p = 0.346). During the median 60-month follow-up period, two subjects in the experimental arm and three in the control arm developed oral cancer. Under the intention-to-treat principle, relative risk by supplementing with beta-carotene and vitamin C was 0.77 (95%CI: 0.28–1.89) (p = 0.580) by the Cox proportional hazards model. No unfavorable side-effects were noted. Beta-carotene (10 mg day−1) and vitamin C were neither effective for clinical remission, nor for protection against the development of cancer. Data from this RCT does not support the hypothesis that chemoprevention with this treatment is effective for oral leukoplakia." @default.
• W1656556746 created "2016-06-24" @default.
• W1656556746 creator A5003548603 @default.
• W1656556746 creator A5004364082 @default.
• W1656556746 creator A5026483615 @default.
• W1656556746 creator A5030079201 @default.
• W1656556746 creator A5035143437 @default.
• W1656556746 creator A5051364873 @default.
• W1656556746 creator A5052304709 @default.
• W1656556746 creator A5083098414 @default.
• W1656556746 creator A5088652438 @default.
• W1656556746 date "2014-09-05" @default.
• W1656556746 modified "2023-09-23" @default.
• W1656556746 title "Treatment of oral leukoplakia with a low-dose of beta-carotene and vitamin C supplements: A randomized controlled trial" @default.
• W1656556746 cites W11619671 @default.
• W1656556746 cites W1493709544 @default.
• W1656556746 cites W1525444530 @default.
• W1656556746 cites W1630865570 @default.
• W1656556746 cites W1894696515 @default.
• W1656556746 cites W1966570365 @default.
• W1656556746 cites W1971380329 @default.
• W1656556746 cites W1982861717 @default.
• W1656556746 cites W1999218614 @default.
• W1656556746 cites W2000079766 @default.
• W1656556746 cites W2004794022 @default.
• W1656556746 cites W2005646554 @default.
• W1656556746 cites W2011663093 @default.
• W1656556746 cites W2018986594 @default.
• W1656556746 cites W2039138723 @default.
• W1656556746 cites W2046103533 @default.
• W1656556746 cites W2054091465 @default.
• W1656556746 cites W2072894301 @default.
• W1656556746 cites W2074267550 @default.
• W1656556746 cites W2075755158 @default.
• W1656556746 cites W2080663586 @default.
• W1656556746 cites W2098689751 @default.
• W1656556746 cites W2121060043 @default.
• W1656556746 cites W2124545632 @default.
• W1656556746 cites W2125237084 @default.
• W1656556746 cites W2128874931 @default.
• W1656556746 cites W2131721640 @default.
• W1656556746 cites W2141680653 @default.
• W1656556746 cites W2154220394 @default.
• W1656556746 cites W2163257247 @default.
• W1656556746 cites W2168387882 @default.
• W1656556746 cites W2170340134 @default.
• W1656556746 cites W2271717367 @default.
• W1656556746 cites W2282166293 @default.
• W1656556746 cites W2314876271 @default.
• W1656556746 cites W2317242858 @default.
• W1656556746 cites W2963426242 @default.
• W1656556746 cites W3024094785 @default.
• W1656556746 cites W88236243 @default.
• W1656556746 doi "https://doi.org/10.1002/ijc.29156" @default.
• W1656556746 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25156040" @default.
• W1656556746 hasPublicationYear "2014" @default.
• W1656556746 type Work @default.
• W1656556746 sameAs 1656556746 @default.
• W1656556746 citedByCount "41" @default.
• W1656556746 countsByYear W16565567462015 @default.
• W1656556746 countsByYear W16565567462016 @default.
• W1656556746 countsByYear W16565567462017 @default.
• W1656556746 countsByYear W16565567462018 @default.
• W1656556746 countsByYear W16565567462019 @default.
• W1656556746 countsByYear W16565567462020 @default.
• W1656556746 countsByYear W16565567462021 @default.
• W1656556746 countsByYear W16565567462022 @default.
• W1656556746 countsByYear W16565567462023 @default.
• W1656556746 crossrefType "journal-article" @default.
• W1656556746 hasAuthorship W1656556746A5003548603 @default.
• W1656556746 hasAuthorship W1656556746A5004364082 @default.
• W1656556746 hasAuthorship W1656556746A5026483615 @default.
• W1656556746 hasAuthorship W1656556746A5030079201 @default.
• W1656556746 hasAuthorship W1656556746A5035143437 @default.
• W1656556746 hasAuthorship W1656556746A5051364873 @default.
• W1656556746 hasAuthorship W1656556746A5052304709 @default.
• W1656556746 hasAuthorship W1656556746A5083098414 @default.
• W1656556746 hasAuthorship W1656556746A5088652438 @default.
• W1656556746 hasConcept C126322002 @default.
• W1656556746 hasConcept C141071460 @default.
• W1656556746 hasConcept C142724271 @default.
• W1656556746 hasConcept C168563851 @default.
• W1656556746 hasConcept C203092338 @default.
• W1656556746 hasConcept C204787440 @default.
• W1656556746 hasConcept C27081682 @default.
• W1656556746 hasConcept C2776940978 @default.
• W1656556746 hasConcept C535046627 @default.
• W1656556746 hasConcept C71924100 @default.
• W1656556746 hasConcept C90924648 @default.
• W1656556746 hasConceptScore W1656556746C126322002 @default.
• W1656556746 hasConceptScore W1656556746C141071460 @default.
• W1656556746 hasConceptScore W1656556746C142724271 @default.
• W1656556746 hasConceptScore W1656556746C168563851 @default.
• W1656556746 hasConceptScore W1656556746C203092338 @default.
• W1656556746 hasConceptScore W1656556746C204787440 @default.
• W1656556746 hasConceptScore W1656556746C27081682 @default.
• W1656556746 hasConceptScore W1656556746C2776940978 @default.
• W1656556746 hasConceptScore W1656556746C535046627 @default.

• next