Matches in SemOpenAlex for { <https://semopenalex.org/work/W165705441> ?p ?o ?g. }
- W165705441 endingPage "85" @default.
- W165705441 startingPage "73" @default.
- W165705441 abstract "The physiological regulation of the intracellular Ca2+ homeostasis and its pathological alteration has been studied in rat and gerbil hippocampal slices using ion-sensitive electrodes and the fluorescence imaging technique. The ischemia-induced intracellular Ca2+ rise, accentuated in the synaptic/dendritic layer of the vulnerable CA1 neurons was observed in vivo and could be replicated at an accelerated time course in the ischemic hippocampal slice superfused with unoxygenated, glucose-free medium. The intracellular Ca2+ loading, thought to be instrumental for the generation of postischemic nerve cell damage, seems to result from an increased Ca2+ release out of intracellular stores as well as from an enhanced synaptic Ca2+ influx. The latter is attributed to a depolarization-induced opening of the voltage-dependent Ca2+ channels and to an uncontrolled influx through upregulated NMDA receptor-operated channels. Such an ischemia-induced upregulation which is reported to occur physiologically by the activation of PKC, is reflected by the selective loss of the depressive control of the synaptic NMDA Ca2+ influx by adenosine. Ischemia also leads to a hypertrophy of astrocytes which may go along with an impairment of their physiological function to take up glutamate adding to the extracellular rise of the excitotoxic amino acids. A pathological activation of microglial cells and their transformation into macrophages, known to release oxygen radicals, may further add to neuronal damage. The observed neuroprotection by adenosine can be primarily ascribed to its limiting effect on a pathological membrane depolarization and its deleterious consequences. The more powerful neuroprotection by propentofylline, thought to act analogue to adenosine, seems to be achieved by additional mechanisms. This pharmacon depresses the ischemia-induced neuronal Ca2+ loading in vivo and in vitro, prevents the activation of astrocytes and interferes with the transformation as well as with the free radical formation of microglia-derived macrophages as demonstrated in complementary studies with fluorescence techniques on cell cultures." @default.
- W165705441 created "2016-06-24" @default.
- W165705441 creator A5009219737 @default.
- W165705441 creator A5025399708 @default.
- W165705441 creator A5029731768 @default.
- W165705441 creator A5046833462 @default.
- W165705441 date "1994-01-01" @default.
- W165705441 modified "2023-10-14" @default.
- W165705441 title "The use of ion-sensitive electrodes and fluorescence imaging in hippocampal slices for studying pathological changes of intracellular Ca2+ regulation" @default.
- W165705441 cites W1601936385 @default.
- W165705441 cites W1965851946 @default.
- W165705441 cites W1970377013 @default.
- W165705441 cites W1973648429 @default.
- W165705441 cites W1982270009 @default.
- W165705441 cites W1987031160 @default.
- W165705441 cites W1991437921 @default.
- W165705441 cites W1997568797 @default.
- W165705441 cites W2007990537 @default.
- W165705441 cites W2018149549 @default.
- W165705441 cites W2021497280 @default.
- W165705441 cites W2028216578 @default.
- W165705441 cites W2028638185 @default.
- W165705441 cites W2030552437 @default.
- W165705441 cites W2038509428 @default.
- W165705441 cites W2054639546 @default.
- W165705441 cites W2062058957 @default.
- W165705441 cites W2074224651 @default.
- W165705441 cites W2077228709 @default.
- W165705441 cites W2083366258 @default.
- W165705441 cites W2113645806 @default.
- W165705441 cites W2116605894 @default.
- W165705441 cites W2128447080 @default.
- W165705441 cites W2141260882 @default.
- W165705441 cites W2186827557 @default.
- W165705441 doi "https://doi.org/10.1007/978-3-7091-9350-1_6" @default.
- W165705441 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7897401" @default.
- W165705441 hasPublicationYear "1994" @default.
- W165705441 type Work @default.
- W165705441 sameAs 165705441 @default.
- W165705441 citedByCount "5" @default.
- W165705441 countsByYear W1657054412018 @default.
- W165705441 countsByYear W1657054412022 @default.
- W165705441 crossrefType "book-chapter" @default.
- W165705441 hasAuthorship W165705441A5009219737 @default.
- W165705441 hasAuthorship W165705441A5025399708 @default.
- W165705441 hasAuthorship W165705441A5029731768 @default.
- W165705441 hasAuthorship W165705441A5046833462 @default.
- W165705441 hasConcept C12554922 @default.
- W165705441 hasConcept C126322002 @default.
- W165705441 hasConcept C148762608 @default.
- W165705441 hasConcept C169760540 @default.
- W165705441 hasConcept C170493617 @default.
- W165705441 hasConcept C185592680 @default.
- W165705441 hasConcept C25498285 @default.
- W165705441 hasConcept C2776991684 @default.
- W165705441 hasConcept C2781012912 @default.
- W165705441 hasConcept C28406088 @default.
- W165705441 hasConcept C4141045 @default.
- W165705441 hasConcept C541997718 @default.
- W165705441 hasConcept C55493867 @default.
- W165705441 hasConcept C61174792 @default.
- W165705441 hasConcept C67018056 @default.
- W165705441 hasConcept C71924100 @default.
- W165705441 hasConcept C79879829 @default.
- W165705441 hasConcept C86803240 @default.
- W165705441 hasConcept C95444343 @default.
- W165705441 hasConceptScore W165705441C12554922 @default.
- W165705441 hasConceptScore W165705441C126322002 @default.
- W165705441 hasConceptScore W165705441C148762608 @default.
- W165705441 hasConceptScore W165705441C169760540 @default.
- W165705441 hasConceptScore W165705441C170493617 @default.
- W165705441 hasConceptScore W165705441C185592680 @default.
- W165705441 hasConceptScore W165705441C25498285 @default.
- W165705441 hasConceptScore W165705441C2776991684 @default.
- W165705441 hasConceptScore W165705441C2781012912 @default.
- W165705441 hasConceptScore W165705441C28406088 @default.
- W165705441 hasConceptScore W165705441C4141045 @default.
- W165705441 hasConceptScore W165705441C541997718 @default.
- W165705441 hasConceptScore W165705441C55493867 @default.
- W165705441 hasConceptScore W165705441C61174792 @default.
- W165705441 hasConceptScore W165705441C67018056 @default.
- W165705441 hasConceptScore W165705441C71924100 @default.
- W165705441 hasConceptScore W165705441C79879829 @default.
- W165705441 hasConceptScore W165705441C86803240 @default.
- W165705441 hasConceptScore W165705441C95444343 @default.
- W165705441 hasLocation W1657054411 @default.
- W165705441 hasLocation W1657054412 @default.
- W165705441 hasOpenAccess W165705441 @default.
- W165705441 hasPrimaryLocation W1657054411 @default.
- W165705441 hasRelatedWork W1997267385 @default.
- W165705441 hasRelatedWork W2011503924 @default.
- W165705441 hasRelatedWork W2014967627 @default.
- W165705441 hasRelatedWork W2022062858 @default.
- W165705441 hasRelatedWork W2084167126 @default.
- W165705441 hasRelatedWork W2099649534 @default.
- W165705441 hasRelatedWork W2373865433 @default.
- W165705441 hasRelatedWork W2417959095 @default.
- W165705441 hasRelatedWork W3146544726 @default.