Matches in SemOpenAlex for { <https://semopenalex.org/work/W1657221871> ?p ?o ?g. }
Showing items 1 to 88 of
88
with 100 items per page.
- W1657221871 endingPage "2688" @default.
- W1657221871 startingPage "2680" @default.
- W1657221871 abstract "Abstract CTL and NK cells share a common cytolytic mechanism that involves regulated exocytosis of lytic molecules stored within cytoplasmic granules. Here we describe the processing, subcellular localization, and function of a T and NK cell-specific granule protein that shares homology with small, lytic granule-associated molecules. The gene coding for this protein, 519, is expressed late after T cell activation. Antisera raised against a 519/glutathione-S-transferase fusion protein and a series of peptides derived from the 519 protein sequence permitted the identification of two small CTL protein products of 15 and 9 kDa that are exocytosed after stimulation through the TCR. The 9-kDa product is a processed form of 519 and differs from the 15-kDa product in both its amino and carboxyl terminus. While both 519 proteins are found in cytoplasmic granules, the 9-kDa form is also present in dense, highly cytolytic granules. Functional studies indicate that this protein is lytic against tumor cell targets. The cell type- and stage-specific expression pattern of 519 along with its subcellular localization are reminiscent of molecules that play a vital role in granule-mediated cytolysis by CTL and NK cells. Its lytic activity suggests the involvement of 519 in CTL effector function." @default.
- W1657221871 created "2016-06-24" @default.
- W1657221871 creator A5019420540 @default.
- W1657221871 creator A5032693585 @default.
- W1657221871 creator A5046871229 @default.
- W1657221871 creator A5080076358 @default.
- W1657221871 creator A5086865556 @default.
- W1657221871 date "1997-03-15" @default.
- W1657221871 modified "2023-10-14" @default.
- W1657221871 title "Processing, subcellular localization, and function of 519 (granulysin), a human late T cell activation molecule with homology to small, lytic, granule proteins." @default.
- W1657221871 doi "https://doi.org/10.4049/jimmunol.158.6.2680" @default.
- W1657221871 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9058801" @default.
- W1657221871 hasPublicationYear "1997" @default.
- W1657221871 type Work @default.
- W1657221871 sameAs 1657221871 @default.
- W1657221871 citedByCount "188" @default.
- W1657221871 countsByYear W16572218712012 @default.
- W1657221871 countsByYear W16572218712013 @default.
- W1657221871 countsByYear W16572218712014 @default.
- W1657221871 countsByYear W16572218712015 @default.
- W1657221871 countsByYear W16572218712016 @default.
- W1657221871 countsByYear W16572218712017 @default.
- W1657221871 countsByYear W16572218712018 @default.
- W1657221871 countsByYear W16572218712019 @default.
- W1657221871 countsByYear W16572218712020 @default.
- W1657221871 countsByYear W16572218712021 @default.
- W1657221871 countsByYear W16572218712022 @default.
- W1657221871 countsByYear W16572218712023 @default.
- W1657221871 crossrefType "journal-article" @default.
- W1657221871 hasAuthorship W1657221871A5019420540 @default.
- W1657221871 hasAuthorship W1657221871A5032693585 @default.
- W1657221871 hasAuthorship W1657221871A5046871229 @default.
- W1657221871 hasAuthorship W1657221871A5080076358 @default.
- W1657221871 hasAuthorship W1657221871A5086865556 @default.
- W1657221871 hasConcept C147969180 @default.
- W1657221871 hasConcept C151730666 @default.
- W1657221871 hasConcept C153911025 @default.
- W1657221871 hasConcept C154317977 @default.
- W1657221871 hasConcept C159047783 @default.
- W1657221871 hasConcept C182615771 @default.
- W1657221871 hasConcept C190062978 @default.
- W1657221871 hasConcept C202751555 @default.
- W1657221871 hasConcept C2522874641 @default.
- W1657221871 hasConcept C2776879804 @default.
- W1657221871 hasConcept C49760210 @default.
- W1657221871 hasConcept C51785407 @default.
- W1657221871 hasConcept C55493867 @default.
- W1657221871 hasConcept C73588182 @default.
- W1657221871 hasConcept C86803240 @default.
- W1657221871 hasConcept C95444343 @default.
- W1657221871 hasConceptScore W1657221871C147969180 @default.
- W1657221871 hasConceptScore W1657221871C151730666 @default.
- W1657221871 hasConceptScore W1657221871C153911025 @default.
- W1657221871 hasConceptScore W1657221871C154317977 @default.
- W1657221871 hasConceptScore W1657221871C159047783 @default.
- W1657221871 hasConceptScore W1657221871C182615771 @default.
- W1657221871 hasConceptScore W1657221871C190062978 @default.
- W1657221871 hasConceptScore W1657221871C202751555 @default.
- W1657221871 hasConceptScore W1657221871C2522874641 @default.
- W1657221871 hasConceptScore W1657221871C2776879804 @default.
- W1657221871 hasConceptScore W1657221871C49760210 @default.
- W1657221871 hasConceptScore W1657221871C51785407 @default.
- W1657221871 hasConceptScore W1657221871C55493867 @default.
- W1657221871 hasConceptScore W1657221871C73588182 @default.
- W1657221871 hasConceptScore W1657221871C86803240 @default.
- W1657221871 hasConceptScore W1657221871C95444343 @default.
- W1657221871 hasIssue "6" @default.
- W1657221871 hasLocation W16572218711 @default.
- W1657221871 hasLocation W16572218712 @default.
- W1657221871 hasOpenAccess W1657221871 @default.
- W1657221871 hasPrimaryLocation W16572218711 @default.
- W1657221871 hasRelatedWork W1542207790 @default.
- W1657221871 hasRelatedWork W154621828 @default.
- W1657221871 hasRelatedWork W1573436053 @default.
- W1657221871 hasRelatedWork W1625385532 @default.
- W1657221871 hasRelatedWork W1991634 @default.
- W1657221871 hasRelatedWork W2094942810 @default.
- W1657221871 hasRelatedWork W2111991328 @default.
- W1657221871 hasRelatedWork W2171414857 @default.
- W1657221871 hasRelatedWork W2171569523 @default.
- W1657221871 hasRelatedWork W2992138720 @default.
- W1657221871 hasVolume "158" @default.
- W1657221871 isParatext "false" @default.
- W1657221871 isRetracted "false" @default.
- W1657221871 magId "1657221871" @default.
- W1657221871 workType "article" @default.