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• W165725879 abstract "The purpose of the studies described in this thesis was to study the purported metabolic effects oftwo dietary agents, L-Histidine and Epigallocatechingallate (EGCG). Supplementation of both LHistidineand pure EGCG in animal models has previously shown effects on components of energybalance and blood glucose regulation. Studies of their supplementation among humans are none (incase of L-Histidine) or very limited (in case of EGCG supplementation). The studies presentedherein are novel as there have been no previous studies conducted to measure their effects onthermogenesis in humans and the present studies are the first to do. Three studies were performedto investigate metabolic effects of L-Histidine and two studies were performed to investigatemetabolic effects of EGCG among healthy men. Duration of supplementation and varying doseswere considered in different studies which led to the variation in study designs and protocols.Effects of L-Histidine: The metabolic effects of the essential amino acid L-Histidine (25 mg/kg) onhealthy and overweight men were investigated in a series of studies. A pilot study was conducted todevelop a protocol for measurement of resting metabolic rate (RMR), mean skin (MST), coretemperature (CT) simultaneously. The protocol implemented was successful and was applied in allfurther studies. This study also examined the effect of L-Histidine supplementation (25 mg/kg) onRMR, MST, CT over a short period (3.25 hours). No conclusive results were obtained from thisstudy. A single blind, placebo controlled cross-over study was then conducted to examine theeffects of 10-day supplementation of L-Histidine on RMR, MST, CT and fasting blood glucose(FBG) in healthy male subjects (n = 9). Following L-Histidine ingestion, mean body weight (p =0.008) and FBG (p = 0.04) were significantly reduced compared to baseline measurements. Arandomised, parallel, single blinded and placebo controlled study was conducted following on fromthis to examine the effects of long-term (8 week, 25 mg/kg/day) intake of L-Histidine on RMR,MST, CT, lipid profile, FBG, insulin, leptin, non-esterified fatty acid (NEFA) and body fatcomposition in overweight and obese but otherwise healthy men (n = 18 (9 participants each inplacebo and L-Histidine group)). Results of this study showed significantly decreased weight after8 weeks (p = 0.007) compared to baseline, irrespective of the type of supplementation. Oralsupplementation of L-Histidine improved FBG concentrations and reduced body weight after 10days’ ingestion, however, no effects of long-term supplementation was established.Effects of EGCG: The second part of this thesis presents studies performed to investigate metaboliceffects of pure EGCG. The first study was randomised, cross-over, placebo controlled and singleblindedin design. the effects of an oral intake of 150 mg pure EGCG over an acute period (2.5hours), on key metabolic parameters and following an oral glucose challenge was measured (n = 8,healthy men). Results of this study were inconclusive on RMR, MST, CT plasma insulin, leptinand NEFA concentrations and appetite regulation. The second study tested the effects of varyingdoses (75, 150 and 300 mg/day) of pure EGCG on afore mentioned key metabolic parameters whensupplemented over a period of 7 days each (n = 8, male). No significant changes in measuredparameters were found. The results of these two studies indicate the need for further studies toinvestigate effects of EGCG on weight loss / weight maintenance possibly in combination withcaffeine and/or other green tea flavanols.Both L-Histidine and EGCG supplmentations have previously shown to influence regulators ofenergy balance, blood glucose and cardiovascular risk factors via activation of the sympatheticnervous system in animal models. The present studies however did not provide any definitiveconclusions following EGCG ingestion in healthy humans. L-Histidine supplementation broughtabout significant decrease in FBG and body weight after 10 days’ ingestion but its effect after 3.25hours and 8 weeks was inconclusive. The effects following supplementation of both L-Histidineand EGCG ingestion needs to be further studied to clarify any potential metabolic consequences inhumans." @default.
• W165725879 created "2016-06-24" @default.
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• W165725879 date "2009-01-01" @default.
• W165725879 modified "2023-09-27" @default.
• W165725879 title "Novel nutritional interventions in the manipulation of energy expenditure and blood glucose regulation in humans" @default.
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