FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1657446100> ?p ?o ?g. }

• W1657446100 endingPage "2819" @default.
• W1657446100 startingPage "2808" @default.
• W1657446100 abstract "The FUS-CHOP fusion protein has been found to be instrumental for specific oncogenic processes in liposarcoma, but its ability to induce metastasis and the underlying mechanisms by which this can be achieved remain unknown. To dissect its functional role in this context, we stably overexpressed this protein in SW872 liposarcoma and HT1080 fibrosarcoma cell lines, and were able to demonstrate that forced expression of FUS-CHOP significantly increases migration and invasion, as well as enhances lung and liver metastasis in the in vivo chicken chorioallantoic membrane (CAM) model, that is proliferation independent. Additionally, FUS-CHOP enhances the expression of matrix-metalloproteinases -2 and -9, and transactivates their promoters in vitro. Mutational analysis showed that C/EBP-β- (-769/-755), NF-κB (-525/-516) and CREB/AP-1 (-218/-207) sites were important for MMP-2 and NF-κB (-604/-598), AP-1 (-539/-532) and AP-1 (-81/-72) for MMP-9 transactivation. Moreover, a direct in vivo interaction of FUS-CHOP was observed in case of the MMP-2 promoter within region (-769/-207). siRNA data revealed that MMP-2 expression is essential in the FUS-CHOP induced metastatic phenotype. MMP-2-mRNA and protein expression correlated significantly with FUS-CHOP positivity in 46 resected patient liposarcoma tissues. We have for the first time provided substantial evidence for the FUS-CHOP oncoprotein as an inducer of metastasis that is due to the transcriptional induction of specific tumor-associated proteases. Insights gained from this study not only support a deeper understanding of the mechanistic properties of FUS-CHOP, but also open up new avenues for targeted therapy." @default.
• W1657446100 created "2016-06-24" @default.
• W1657446100 creator A5000118767 @default.
• W1657446100 creator A5025744948 @default.
• W1657446100 creator A5040815462 @default.
• W1657446100 creator A5043829083 @default.
• W1657446100 creator A5070918924 @default.
• W1657446100 creator A5075338963 @default.
• W1657446100 date "2013-12-07" @default.
• W1657446100 modified "2023-10-05" @default.
• W1657446100 title "A mechanistic study on the metastasis inducing function of FUS-CHOP fusion protein in liposarcoma" @default.
• W1657446100 cites W1520425169 @default.
• W1657446100 cites W1860918802 @default.
• W1657446100 cites W1973840375 @default.
• W1657446100 cites W1974281992 @default.
• W1657446100 cites W1976689131 @default.
• W1657446100 cites W1977694859 @default.
• W1657446100 cites W1987449626 @default.
• W1657446100 cites W1992885568 @default.
• W1657446100 cites W2004244160 @default.
• W1657446100 cites W2007506965 @default.
• W1657446100 cites W2016558681 @default.
• W1657446100 cites W2017875552 @default.
• W1657446100 cites W2018134201 @default.
• W1657446100 cites W2021049963 @default.
• W1657446100 cites W2027632544 @default.
• W1657446100 cites W2029637670 @default.
• W1657446100 cites W2033119603 @default.
• W1657446100 cites W2033994846 @default.
• W1657446100 cites W2038623184 @default.
• W1657446100 cites W2044490076 @default.
• W1657446100 cites W2059707627 @default.
• W1657446100 cites W2060131076 @default.
• W1657446100 cites W2070595030 @default.
• W1657446100 cites W2074706587 @default.
• W1657446100 cites W2075185862 @default.
• W1657446100 cites W2089370460 @default.
• W1657446100 cites W2091563046 @default.
• W1657446100 cites W2095922581 @default.
• W1657446100 cites W2096379342 @default.
• W1657446100 cites W2104440522 @default.
• W1657446100 cites W2107989095 @default.
• W1657446100 cites W2139233834 @default.
• W1657446100 cites W2147913714 @default.
• W1657446100 cites W2164322102 @default.
• W1657446100 cites W2171340008 @default.
• W1657446100 cites W987729868 @default.
• W1657446100 doi "https://doi.org/10.1002/ijc.28638" @default.
• W1657446100 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24285420" @default.
• W1657446100 hasPublicationYear "2013" @default.
• W1657446100 type Work @default.
• W1657446100 sameAs 1657446100 @default.
• W1657446100 citedByCount "12" @default.
• W1657446100 countsByYear W16574461002012 @default.
• W1657446100 countsByYear W16574461002016 @default.
• W1657446100 countsByYear W16574461002017 @default.
• W1657446100 countsByYear W16574461002018 @default.
• W1657446100 countsByYear W16574461002019 @default.
• W1657446100 countsByYear W16574461002020 @default.
• W1657446100 countsByYear W16574461002021 @default.
• W1657446100 countsByYear W16574461002022 @default.
• W1657446100 crossrefType "journal-article" @default.
• W1657446100 hasAuthorship W1657446100A5000118767 @default.
• W1657446100 hasAuthorship W1657446100A5025744948 @default.
• W1657446100 hasAuthorship W1657446100A5040815462 @default.
• W1657446100 hasAuthorship W1657446100A5043829083 @default.
• W1657446100 hasAuthorship W1657446100A5070918924 @default.
• W1657446100 hasAuthorship W1657446100A5075338963 @default.
• W1657446100 hasBestOaLocation W16574461001 @default.
• W1657446100 hasConcept C104317684 @default.
• W1657446100 hasConcept C121608353 @default.
• W1657446100 hasConcept C1292079 @default.
• W1657446100 hasConcept C142724271 @default.
• W1657446100 hasConcept C158617107 @default.
• W1657446100 hasConcept C2777751087 @default.
• W1657446100 hasConcept C2778256501 @default.
• W1657446100 hasConcept C2779013556 @default.
• W1657446100 hasConcept C2779568860 @default.
• W1657446100 hasConcept C2779725641 @default.
• W1657446100 hasConcept C3020616263 @default.
• W1657446100 hasConcept C502942594 @default.
• W1657446100 hasConcept C54355233 @default.
• W1657446100 hasConcept C71924100 @default.
• W1657446100 hasConcept C86339819 @default.
• W1657446100 hasConcept C86803240 @default.
• W1657446100 hasConcept C95444343 @default.
• W1657446100 hasConceptScore W1657446100C104317684 @default.
• W1657446100 hasConceptScore W1657446100C121608353 @default.
• W1657446100 hasConceptScore W1657446100C1292079 @default.
• W1657446100 hasConceptScore W1657446100C142724271 @default.
• W1657446100 hasConceptScore W1657446100C158617107 @default.
• W1657446100 hasConceptScore W1657446100C2777751087 @default.
• W1657446100 hasConceptScore W1657446100C2778256501 @default.
• W1657446100 hasConceptScore W1657446100C2779013556 @default.
• W1657446100 hasConceptScore W1657446100C2779568860 @default.
• W1657446100 hasConceptScore W1657446100C2779725641 @default.
• W1657446100 hasConceptScore W1657446100C3020616263 @default.
• W1657446100 hasConceptScore W1657446100C502942594 @default.

• next