Matches in SemOpenAlex for { <https://semopenalex.org/work/W1657726410> ?p ?o ?g. }
Showing items 1 to 80 of
80
with 100 items per page.
- W1657726410 endingPage "2426" @default.
- W1657726410 startingPage "2419" @default.
- W1657726410 abstract "Abstract Isolated membrane vesicles from Escherichia coli K-12 rapidly degrade adenosine to adenine and inosine to hypoxanthine, using membrane-localized nucleoside phosphorylase activity, without transporting them across the membrane. The free bases are then transported and accumulated intravesicularly as the nucleoside monophosphate. The kinetics of formation of the nucleoside monophosphates, AMP and IMP, respectively, shows the same response to temperature, 5-phosphoribosyl-1-pyrophosphate concentration, and nucleotide inhibitors whether the free base or ribonucleoside is the substrate for uptake. The mechanism of purine nucleoside uptake in E. coli is therefore postulated to occur by two enzymatic steps involving two membrane enzymes: (a) extramembranal cleavage of nucleoside to free base and (b) group translocation of the free bases mediated by membrane phosphoribosyltransferases resulting in the intramembranal accumulation of nucleoside monophosphate. The second reaction is the means of adenine and hypoxanthine uptake and therefore the utilization of free purine base and purine nucleoside share a common pathway in this organism. The kinetics of uptake with respect to concentration of nucleoside or free base suggests that there may be interaction or association, or both, between the two enzymes themselves on the membrane surface." @default.
- W1657726410 created "2016-06-24" @default.
- W1657726410 creator A5075951101 @default.
- W1657726410 date "1972-04-01" @default.
- W1657726410 modified "2023-09-30" @default.
- W1657726410 title "The Regulation of Purine Utilization in Bacteria" @default.
- W1657726410 cites W129959766 @default.
- W1657726410 cites W1537919308 @default.
- W1657726410 cites W1548284545 @default.
- W1657726410 cites W1548625092 @default.
- W1657726410 cites W1557949336 @default.
- W1657726410 cites W1568190283 @default.
- W1657726410 cites W1592356287 @default.
- W1657726410 cites W1596028753 @default.
- W1657726410 cites W1600528069 @default.
- W1657726410 cites W1605287388 @default.
- W1657726410 cites W1657331296 @default.
- W1657726410 cites W1750537754 @default.
- W1657726410 cites W1968723655 @default.
- W1657726410 cites W1989504459 @default.
- W1657726410 cites W2007798738 @default.
- W1657726410 cites W2011438247 @default.
- W1657726410 cites W2023193278 @default.
- W1657726410 cites W2040295869 @default.
- W1657726410 cites W2041079513 @default.
- W1657726410 cites W2054764193 @default.
- W1657726410 cites W2064516984 @default.
- W1657726410 cites W2069847692 @default.
- W1657726410 cites W2093669081 @default.
- W1657726410 cites W2129604971 @default.
- W1657726410 cites W2322018161 @default.
- W1657726410 cites W2339953965 @default.
- W1657726410 cites W4255923060 @default.
- W1657726410 doi "https://doi.org/10.1016/s0021-9258(19)45445-8" @default.
- W1657726410 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/4336374" @default.
- W1657726410 hasPublicationYear "1972" @default.
- W1657726410 type Work @default.
- W1657726410 sameAs 1657726410 @default.
- W1657726410 citedByCount "48" @default.
- W1657726410 countsByYear W16577264102016 @default.
- W1657726410 crossrefType "journal-article" @default.
- W1657726410 hasAuthorship W1657726410A5075951101 @default.
- W1657726410 hasBestOaLocation W16577264101 @default.
- W1657726410 hasConcept C169586020 @default.
- W1657726410 hasConcept C181199279 @default.
- W1657726410 hasConcept C185592680 @default.
- W1657726410 hasConcept C2776476023 @default.
- W1657726410 hasConcept C523546767 @default.
- W1657726410 hasConcept C54355233 @default.
- W1657726410 hasConcept C55493867 @default.
- W1657726410 hasConcept C86803240 @default.
- W1657726410 hasConceptScore W1657726410C169586020 @default.
- W1657726410 hasConceptScore W1657726410C181199279 @default.
- W1657726410 hasConceptScore W1657726410C185592680 @default.
- W1657726410 hasConceptScore W1657726410C2776476023 @default.
- W1657726410 hasConceptScore W1657726410C523546767 @default.
- W1657726410 hasConceptScore W1657726410C54355233 @default.
- W1657726410 hasConceptScore W1657726410C55493867 @default.
- W1657726410 hasConceptScore W1657726410C86803240 @default.
- W1657726410 hasIssue "8" @default.
- W1657726410 hasLocation W16577264101 @default.
- W1657726410 hasOpenAccess W1657726410 @default.
- W1657726410 hasPrimaryLocation W16577264101 @default.
- W1657726410 hasRelatedWork W1600008047 @default.
- W1657726410 hasRelatedWork W1880490063 @default.
- W1657726410 hasRelatedWork W1980060818 @default.
- W1657726410 hasRelatedWork W1995270105 @default.
- W1657726410 hasRelatedWork W2003714719 @default.
- W1657726410 hasRelatedWork W2046925551 @default.
- W1657726410 hasRelatedWork W2231358623 @default.
- W1657726410 hasRelatedWork W2413319058 @default.
- W1657726410 hasRelatedWork W2950687088 @default.
- W1657726410 hasRelatedWork W54361237 @default.
- W1657726410 hasVolume "247" @default.
- W1657726410 isParatext "false" @default.
- W1657726410 isRetracted "false" @default.
- W1657726410 magId "1657726410" @default.
- W1657726410 workType "article" @default.