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- W165784751 abstract "Abstract Background: In preterm infants both hypo- and hyperglycemia are a frequent problem. Intravenous lipids can affect glucose metabolism by stimulation of gluconeogenesis by providing glycerol, a gluconeogenic precursor, and/or by providing free fatty acids (FFA), stimulants of the rate of gluconeogenesis. Methods: In 25 preterm infants glucose production and gluconeogenesis were measured using stable isotope techniques, during a six-hour infusion of glucose only, glucose plus glycerol, or glucose plus an intravenous lipid emulsion. Two lipid emulsions differing in FFA composition were used: Intralipid ® (~60% polyunsaturated FFA) and Clinoleic ® (~60% monounsaturated FFA). The rate of glucose infusion was 22 µmol.kg -1 .min -1 in all groups.Results: During the study-infusion the FFA concentrations were higher in both lipid groups compared to the glycerol group (p<0.001). Compared to baseline, the glucose production rate increased in the Intralipid ® group, whereas it decreased in the other groups (p=0.002), due to a significant increase in gluconeogenesis in the Intralipid" @default.
- W165784751 created "2016-06-24" @default.
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- W165784751 date "2005-01-01" @default.
- W165784751 modified "2023-09-27" @default.
- W165784751 title "Running title: FFA and gluconeogenesis in preterm infants" @default.
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