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- W165788424 abstract "The ability of 5-HT3receptor antagonists such as ondansetron, tropisetron, and granisetron to prevent chemotherapy-and radiation-induced emesis in animal models has been confirmed in the clinic. In both animals and man the antiemetic effects have been attributed to a selective blockade of 5-HT3receptors located centrally in the area postrema and nucleus tractus solitarius and peripherally, on the afferent fibers of the vagus nerve in the gastrointestinal tract. The recent clinical demonstration of the efficacy of ondansetron in postoperative nausea and vomiting may also involve a 5-HT3receptor antagonism at central and peripheral sites. The breadth of action of ondansetron reveals the 5-HT3receptor antagonists as an important new therapy for the treatment of emesis." @default.
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- W165788424 date "1993-01-01" @default.
- W165788424 modified "2023-09-24" @default.
- W165788424 title "The Antiemetic Properties of 5-HT3Receptor Antagonists" @default.
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