Matches in SemOpenAlex for { <https://semopenalex.org/work/W1657979912> ?p ?o ?g. }
Showing items 1 to 100 of
100
with 100 items per page.
- W1657979912 abstract "Metastasis is the spread of cancer cells throughout the body. Although it is frequently the cause of death from malignant growths, it is the most poorly understood aspect of carcinogenesis. The underlying process of cancer cell dissemination is controlled by genetic programs in the tumour cells and in the host. The tumour cell-intrinsic genetic programs of metastasis confer invasiveness and anchorage-independence. The responsible genes are typically deregulated by aberrant expression or splicing. Organ preference of metastasis depends on more complex tumour–host interactions. Metastasis suppressor genes, when expressed, can negatively regulate tumour spread. The molecular genetics of metastasis has led to the development of diagnostic tests, based on gene expression profiles that help predict metastatic potential. Further, it has opened prospects for the targeting of key culprit genes in antimetastasis therapy.Key Concepts: Cancer invasiveness constitutes the breaking of tumour cells through tissue barriers and represents the earliest manifestation of metastasis.The genetic basis of metastasis formation is the aberrant expression or splicing of stress response genes.The biologic activity of metastasis-mediating gene products is extensively regulated by posttranscriptional mechanisms.Cancer metastasis is guided by two intrinsic characteristics of cancer cells, invasiveness and anchorage-independent survival.Cancer cell invasiveness is mediated by secreted proteases, homing receptors, cytokine ligands and associated signalling molecules.The acquisition of invasiveness by tumour cells is accompanied by a characteristic, reversible remodelling, called the epithelial-mesenchymal transition.Cancers shed their tumour cells into the blood or lymph stream from the earliest stages of growth on; most cells die in the circulation.Fully transformed cells can survive without anchorage for extended periods of time.Genetic programs of metastasis encode consistent patterns of organ preference by individual malignancies.Like other functions within cancer cells, the ability to metastasise is under positive and negative genetic control.Keywords:metastasis;invasion;anoikis;homing receptor;cytokine;protease" @default.
- W1657979912 created "2016-06-24" @default.
- W1657979912 creator A5018255697 @default.
- W1657979912 date "2017-07-17" @default.
- W1657979912 modified "2023-09-26" @default.
- W1657979912 title "Molecular Genetics of Metastasis" @default.
- W1657979912 cites W1338787 @default.
- W1657979912 cites W1944951884 @default.
- W1657979912 cites W1963965802 @default.
- W1657979912 cites W1966873816 @default.
- W1657979912 cites W1970784817 @default.
- W1657979912 cites W1971624340 @default.
- W1657979912 cites W1971992633 @default.
- W1657979912 cites W1985585224 @default.
- W1657979912 cites W1986471913 @default.
- W1657979912 cites W1987660792 @default.
- W1657979912 cites W2009096543 @default.
- W1657979912 cites W2012839093 @default.
- W1657979912 cites W2014691022 @default.
- W1657979912 cites W2022676856 @default.
- W1657979912 cites W2027775756 @default.
- W1657979912 cites W2030729827 @default.
- W1657979912 cites W2038511343 @default.
- W1657979912 cites W2057151160 @default.
- W1657979912 cites W2086510790 @default.
- W1657979912 cites W2089370460 @default.
- W1657979912 cites W2092754755 @default.
- W1657979912 cites W2092868756 @default.
- W1657979912 cites W2093464881 @default.
- W1657979912 cites W2095641625 @default.
- W1657979912 cites W2104159239 @default.
- W1657979912 cites W2105592383 @default.
- W1657979912 cites W2122555310 @default.
- W1657979912 cites W2124559417 @default.
- W1657979912 cites W2128410150 @default.
- W1657979912 cites W2133683998 @default.
- W1657979912 cites W2137022580 @default.
- W1657979912 cites W2146530991 @default.
- W1657979912 cites W2146678830 @default.
- W1657979912 cites W2156323704 @default.
- W1657979912 cites W2317350790 @default.
- W1657979912 cites W2412607353 @default.
- W1657979912 cites W4213424167 @default.
- W1657979912 doi "https://doi.org/10.1002/9780470015902.a0022447.pub2" @default.
- W1657979912 hasPublicationYear "2017" @default.
- W1657979912 type Work @default.
- W1657979912 sameAs 1657979912 @default.
- W1657979912 citedByCount "1" @default.
- W1657979912 countsByYear W16579799122021 @default.
- W1657979912 crossrefType "reference-entry" @default.
- W1657979912 hasAuthorship W1657979912A5018255697 @default.
- W1657979912 hasConcept C121608353 @default.
- W1657979912 hasConcept C151872237 @default.
- W1657979912 hasConcept C18903297 @default.
- W1657979912 hasConcept C2779013556 @default.
- W1657979912 hasConcept C2909960190 @default.
- W1657979912 hasConcept C502942594 @default.
- W1657979912 hasConcept C54355233 @default.
- W1657979912 hasConcept C555283112 @default.
- W1657979912 hasConcept C76419328 @default.
- W1657979912 hasConcept C86803240 @default.
- W1657979912 hasConcept C96232424 @default.
- W1657979912 hasConceptScore W1657979912C121608353 @default.
- W1657979912 hasConceptScore W1657979912C151872237 @default.
- W1657979912 hasConceptScore W1657979912C18903297 @default.
- W1657979912 hasConceptScore W1657979912C2779013556 @default.
- W1657979912 hasConceptScore W1657979912C2909960190 @default.
- W1657979912 hasConceptScore W1657979912C502942594 @default.
- W1657979912 hasConceptScore W1657979912C54355233 @default.
- W1657979912 hasConceptScore W1657979912C555283112 @default.
- W1657979912 hasConceptScore W1657979912C76419328 @default.
- W1657979912 hasConceptScore W1657979912C86803240 @default.
- W1657979912 hasConceptScore W1657979912C96232424 @default.
- W1657979912 hasLocation W16579799121 @default.
- W1657979912 hasOpenAccess W1657979912 @default.
- W1657979912 hasPrimaryLocation W16579799121 @default.
- W1657979912 hasRelatedWork W1529032434 @default.
- W1657979912 hasRelatedWork W1601028323 @default.
- W1657979912 hasRelatedWork W1964705591 @default.
- W1657979912 hasRelatedWork W1982702686 @default.
- W1657979912 hasRelatedWork W2016048956 @default.
- W1657979912 hasRelatedWork W2084867085 @default.
- W1657979912 hasRelatedWork W2096262488 @default.
- W1657979912 hasRelatedWork W2106505027 @default.
- W1657979912 hasRelatedWork W2187228762 @default.
- W1657979912 hasRelatedWork W2189684928 @default.
- W1657979912 hasRelatedWork W2287446772 @default.
- W1657979912 hasRelatedWork W23287815 @default.
- W1657979912 hasRelatedWork W2411806526 @default.
- W1657979912 hasRelatedWork W2564482541 @default.
- W1657979912 hasRelatedWork W2587657919 @default.
- W1657979912 hasRelatedWork W2874303161 @default.
- W1657979912 hasRelatedWork W3113172645 @default.
- W1657979912 hasRelatedWork W3168612589 @default.
- W1657979912 hasRelatedWork W626431186 @default.
- W1657979912 hasRelatedWork W64280241 @default.
- W1657979912 isParatext "false" @default.
- W1657979912 isRetracted "false" @default.
- W1657979912 magId "1657979912" @default.
- W1657979912 workType "reference-entry" @default.