Matches in SemOpenAlex for { <https://semopenalex.org/work/W1657989568> ?p ?o ?g. }
Showing items 1 to 93 of
93
with 100 items per page.
- W1657989568 endingPage "881" @default.
- W1657989568 startingPage "878" @default.
- W1657989568 abstract "A role for β-amyloid precursor protein (β-APP) in the development of Alzheimer's disease has been indicated by genetics1, and many conditions in which β-APP is raised have been associated with an increased risk of Alzheimer's disease or an Alzheimer's-like pathology2,3,4. Inflammatory events may also contribute to Alzheimer's disease5. Here we investigate whether a secreted derivative of β-APP (sAPP-α) can induce inflammatory reactions in microglia, which are brain cells of monocytic lineage. We found that treatment with sAPP-α increased markers of activation in microglia and enhanced their production of neurotoxins. The ability of sAPP-α to activate microglia was blocked by prior incubation of the protein with apolipoprotein E3 but not apolipoprotein E4, a variant associated with an increased risk for Alzheimer's6. A product of amyloidogenic β-APP processing (sAPP-β) also activated microglia. Because sAPP-β is deficient in the neuroprotective activity shown by sAPP-α, our results indicate that increased amyloidogenic processing could adversely affect the balance of sAPP activities that determine neuronal viability." @default.
- W1657989568 created "2016-06-24" @default.
- W1657989568 creator A5014478943 @default.
- W1657989568 creator A5040994368 @default.
- W1657989568 date "1997-08-01" @default.
- W1657989568 modified "2023-10-09" @default.
- W1657989568 title "Microglial activation by Alzheimer amyloid precursor protein and modulation by apolipoprotein E" @default.
- W1657989568 cites W1991763618 @default.
- W1657989568 cites W2049167261 @default.
- W1657989568 cites W2060633018 @default.
- W1657989568 doi "https://doi.org/10.1038/42257" @default.
- W1657989568 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9278049" @default.
- W1657989568 hasPublicationYear "1997" @default.
- W1657989568 type Work @default.
- W1657989568 sameAs 1657989568 @default.
- W1657989568 citedByCount "579" @default.
- W1657989568 countsByYear W16579895682012 @default.
- W1657989568 countsByYear W16579895682013 @default.
- W1657989568 countsByYear W16579895682014 @default.
- W1657989568 countsByYear W16579895682015 @default.
- W1657989568 countsByYear W16579895682016 @default.
- W1657989568 countsByYear W16579895682017 @default.
- W1657989568 countsByYear W16579895682018 @default.
- W1657989568 countsByYear W16579895682019 @default.
- W1657989568 countsByYear W16579895682020 @default.
- W1657989568 countsByYear W16579895682021 @default.
- W1657989568 countsByYear W16579895682022 @default.
- W1657989568 countsByYear W16579895682023 @default.
- W1657989568 crossrefType "journal-article" @default.
- W1657989568 hasAuthorship W1657989568A5014478943 @default.
- W1657989568 hasAuthorship W1657989568A5040994368 @default.
- W1657989568 hasBestOaLocation W16579895681 @default.
- W1657989568 hasConcept C126322002 @default.
- W1657989568 hasConcept C169760540 @default.
- W1657989568 hasConcept C177907266 @default.
- W1657989568 hasConcept C179104552 @default.
- W1657989568 hasConcept C185592680 @default.
- W1657989568 hasConcept C25498285 @default.
- W1657989568 hasConcept C2776914184 @default.
- W1657989568 hasConcept C2777633098 @default.
- W1657989568 hasConcept C2778163477 @default.
- W1657989568 hasConcept C2779134260 @default.
- W1657989568 hasConcept C2779830541 @default.
- W1657989568 hasConcept C31705614 @default.
- W1657989568 hasConcept C502032728 @default.
- W1657989568 hasConcept C55493867 @default.
- W1657989568 hasConcept C57089818 @default.
- W1657989568 hasConcept C62746215 @default.
- W1657989568 hasConcept C71924100 @default.
- W1657989568 hasConcept C86803240 @default.
- W1657989568 hasConcept C87753298 @default.
- W1657989568 hasConcept C95444343 @default.
- W1657989568 hasConceptScore W1657989568C126322002 @default.
- W1657989568 hasConceptScore W1657989568C169760540 @default.
- W1657989568 hasConceptScore W1657989568C177907266 @default.
- W1657989568 hasConceptScore W1657989568C179104552 @default.
- W1657989568 hasConceptScore W1657989568C185592680 @default.
- W1657989568 hasConceptScore W1657989568C25498285 @default.
- W1657989568 hasConceptScore W1657989568C2776914184 @default.
- W1657989568 hasConceptScore W1657989568C2777633098 @default.
- W1657989568 hasConceptScore W1657989568C2778163477 @default.
- W1657989568 hasConceptScore W1657989568C2779134260 @default.
- W1657989568 hasConceptScore W1657989568C2779830541 @default.
- W1657989568 hasConceptScore W1657989568C31705614 @default.
- W1657989568 hasConceptScore W1657989568C502032728 @default.
- W1657989568 hasConceptScore W1657989568C55493867 @default.
- W1657989568 hasConceptScore W1657989568C57089818 @default.
- W1657989568 hasConceptScore W1657989568C62746215 @default.
- W1657989568 hasConceptScore W1657989568C71924100 @default.
- W1657989568 hasConceptScore W1657989568C86803240 @default.
- W1657989568 hasConceptScore W1657989568C87753298 @default.
- W1657989568 hasConceptScore W1657989568C95444343 @default.
- W1657989568 hasIssue "6645" @default.
- W1657989568 hasLocation W16579895681 @default.
- W1657989568 hasOpenAccess W1657989568 @default.
- W1657989568 hasPrimaryLocation W16579895681 @default.
- W1657989568 hasRelatedWork W1657989568 @default.
- W1657989568 hasRelatedWork W2010167499 @default.
- W1657989568 hasRelatedWork W2010583235 @default.
- W1657989568 hasRelatedWork W2046713500 @default.
- W1657989568 hasRelatedWork W2060955976 @default.
- W1657989568 hasRelatedWork W2063316101 @default.
- W1657989568 hasRelatedWork W2155894885 @default.
- W1657989568 hasRelatedWork W2583830178 @default.
- W1657989568 hasRelatedWork W299188937 @default.
- W1657989568 hasRelatedWork W4200141589 @default.
- W1657989568 hasVolume "388" @default.
- W1657989568 isParatext "false" @default.
- W1657989568 isRetracted "false" @default.
- W1657989568 magId "1657989568" @default.
- W1657989568 workType "article" @default.