Matches in SemOpenAlex for { <https://semopenalex.org/work/W1658105359> ?p ?o ?g. }
- W1658105359 endingPage "3591" @default.
- W1658105359 startingPage "3583" @default.
- W1658105359 abstract "Abstract In H2-DM mutant mice, most MHC class II molecules are bound by a single peptide, CLIP, derived from the class II-associated invariant chain. Previous studies showed that H2-DM− cells are defective in presenting synthetic peptides to class II-restricted T cells. In sharp contrast, however, the same peptides elicited strong CD4+ T cell responses in H2-DM− animals. We now provide an explanation for this apparent discrepancy. Peptide-specific CD4+ T cells from wild-type mice were efficiently stimulated by H2-DM+, but not by H2-DM− cells pulsed with the cognate peptide. In sharp contrast, CD4+ T cells from mutant animals specific for the same MHC-peptide combination recognized peptide-pulsed H2-DM+ and H2-DM− cells equally well. In addition, unlike Ag-specific T cells from wild-type animals, the reactivities of peptide-specific T cells from mutant animals could not be efficiently blocked by Abs specific for the cognate MHC class II-peptide combination. We further demonstrated that the distinct reactivities of CD4+ T cells from H2-DM+ and H2-DM− mice are due to differences in thymic selection. Collectively, these findings indicate that the CD4+ T cell repertoires of H2-DM+ and H2-DM− mice are remarkably different." @default.
- W1658105359 created "2016-06-24" @default.
- W1658105359 creator A5084007601 @default.
- W1658105359 creator A5086911304 @default.
- W1658105359 date "1999-10-01" @default.
- W1658105359 modified "2023-10-15" @default.
- W1658105359 title "Unexpected Reactivities of T Cells Selected by a Single MHC-Peptide Ligand" @default.
- W1658105359 cites W144552556 @default.
- W1658105359 cites W15081168 @default.
- W1658105359 cites W1525018108 @default.
- W1658105359 cites W1584454554 @default.
- W1658105359 cites W1964964271 @default.
- W1658105359 cites W1970621786 @default.
- W1658105359 cites W1974532557 @default.
- W1658105359 cites W1976703529 @default.
- W1658105359 cites W1982319833 @default.
- W1658105359 cites W1995668947 @default.
- W1658105359 cites W1999994822 @default.
- W1658105359 cites W2000262156 @default.
- W1658105359 cites W2001091352 @default.
- W1658105359 cites W2001513404 @default.
- W1658105359 cites W2008329899 @default.
- W1658105359 cites W2009401513 @default.
- W1658105359 cites W2013271672 @default.
- W1658105359 cites W2017584066 @default.
- W1658105359 cites W2023249971 @default.
- W1658105359 cites W2029323607 @default.
- W1658105359 cites W2040392199 @default.
- W1658105359 cites W2047218593 @default.
- W1658105359 cites W2051478400 @default.
- W1658105359 cites W2060264122 @default.
- W1658105359 cites W2065042783 @default.
- W1658105359 cites W2076274640 @default.
- W1658105359 cites W2081492605 @default.
- W1658105359 cites W2083756044 @default.
- W1658105359 cites W2092500909 @default.
- W1658105359 cites W2092847969 @default.
- W1658105359 cites W2141888136 @default.
- W1658105359 cites W2615548860 @default.
- W1658105359 doi "https://doi.org/10.4049/jimmunol.163.7.3583" @default.
- W1658105359 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10490950" @default.
- W1658105359 hasPublicationYear "1999" @default.
- W1658105359 type Work @default.
- W1658105359 sameAs 1658105359 @default.
- W1658105359 citedByCount "11" @default.
- W1658105359 crossrefType "journal-article" @default.
- W1658105359 hasAuthorship W1658105359A5084007601 @default.
- W1658105359 hasAuthorship W1658105359A5086911304 @default.
- W1658105359 hasBestOaLocation W16581053591 @default.
- W1658105359 hasConcept C104317684 @default.
- W1658105359 hasConcept C143065580 @default.
- W1658105359 hasConcept C147483822 @default.
- W1658105359 hasConcept C153911025 @default.
- W1658105359 hasConcept C170627219 @default.
- W1658105359 hasConcept C185592680 @default.
- W1658105359 hasConcept C197695756 @default.
- W1658105359 hasConcept C203014093 @default.
- W1658105359 hasConcept C207936829 @default.
- W1658105359 hasConcept C2776090121 @default.
- W1658105359 hasConcept C2778814158 @default.
- W1658105359 hasConcept C2779281246 @default.
- W1658105359 hasConcept C55493867 @default.
- W1658105359 hasConcept C86803240 @default.
- W1658105359 hasConcept C8891405 @default.
- W1658105359 hasConcept C95444343 @default.
- W1658105359 hasConceptScore W1658105359C104317684 @default.
- W1658105359 hasConceptScore W1658105359C143065580 @default.
- W1658105359 hasConceptScore W1658105359C147483822 @default.
- W1658105359 hasConceptScore W1658105359C153911025 @default.
- W1658105359 hasConceptScore W1658105359C170627219 @default.
- W1658105359 hasConceptScore W1658105359C185592680 @default.
- W1658105359 hasConceptScore W1658105359C197695756 @default.
- W1658105359 hasConceptScore W1658105359C203014093 @default.
- W1658105359 hasConceptScore W1658105359C207936829 @default.
- W1658105359 hasConceptScore W1658105359C2776090121 @default.
- W1658105359 hasConceptScore W1658105359C2778814158 @default.
- W1658105359 hasConceptScore W1658105359C2779281246 @default.
- W1658105359 hasConceptScore W1658105359C55493867 @default.
- W1658105359 hasConceptScore W1658105359C86803240 @default.
- W1658105359 hasConceptScore W1658105359C8891405 @default.
- W1658105359 hasConceptScore W1658105359C95444343 @default.
- W1658105359 hasIssue "7" @default.
- W1658105359 hasLocation W16581053591 @default.
- W1658105359 hasLocation W16581053592 @default.
- W1658105359 hasOpenAccess W1658105359 @default.
- W1658105359 hasPrimaryLocation W16581053591 @default.
- W1658105359 hasRelatedWork W1607130586 @default.
- W1658105359 hasRelatedWork W1840653008 @default.
- W1658105359 hasRelatedWork W1939527068 @default.
- W1658105359 hasRelatedWork W1990236719 @default.
- W1658105359 hasRelatedWork W2023967363 @default.
- W1658105359 hasRelatedWork W2161221618 @default.
- W1658105359 hasRelatedWork W2514929667 @default.
- W1658105359 hasRelatedWork W2979173476 @default.
- W1658105359 hasRelatedWork W4281625971 @default.
- W1658105359 hasRelatedWork W51988033 @default.
- W1658105359 hasVolume "163" @default.
- W1658105359 isParatext "false" @default.