FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1659189991> ?p ?o ?g. }

• W1659189991 endingPage "9" @default.
• W1659189991 startingPage "5154" @default.
• W1659189991 abstract "2-Amino-3,8-dimethylimidazo[4,5-f]quinoxaline (MeIQx), a major heterocyclic aromatic amine (HAA) formed in cooked meats, is metabolically transformed to mutagenic/carcinogenic intermediates. Cytochrome P4501A2 (CYP1A2)-mediated N-hydroxylation followed by phase II O-esterification by N-acetyltransferase (NAT2) are generally regarded as activation processes in which MeIQx and other HAAs are converted to genotoxic species. In this study, we determined the relationship between the activities of these two enzymes and the urinary excretion level of the N2-glucuronide conjugate of 2-hydroxyamino-MeIQx--N2-(beta-1-glucosiduronyl)-2-hydroxyam ino-3,8-dimethylimidazo[4,5-f]quinoxaline (N-OH-MeIQx-N2-glucuronide)--among healthy subjects fed a uniform diet containing high-temperature cooked meat. The individuals (n = 66) in the study ate meat containing known amounts of MeIQx, and urine was collected from 0 to 12 h after the meal. After addition of the deuterium-labeled internal standard to urine, N-OH-MeIQx-N2-glucuronide was isolated using solid-phase extraction and immunoaffinity separation. The isolated conjugate was converted to the deaminated product 2-hydroxy-3,8-dimethylimidazo[4,5-f]quinoxaline (2-OH-MeIQx) by heating with acetic acid. 2-OH-MeIQx and its deuterated analogue were derivatized to form the corresponding 3,5-bis(trifluoromethyl)benzyl ether derivatives and analyzed by capillary gas chromatography-negative ion chemical ionization mass spectrometry using selected ion monitoring procedures. The subjects in the study excreted an average of 9.4 +/- 3.0% (+/-SD) of an ingested dose of MeIQx as N-OH-MeIQx-N2-glucuronide in urine; the range varied from 2.2 to 17.1%. A significant correlation was found between the level of N-OH-MeIQx-N2-glucuronide in urine and the amount of MeIQx ingested (r(s) = 0.44; P = 0.0002). The excretion level of N-OH-MeIQx-N2-glucuronide in urine was not associated with the enzyme activities of NAT2 or CYP1A2. This is expected with the latter enzyme because the metabolism of MeIQx is first order and very rapid at the amounts ingested. The amount of N-OH-MeIQx-N2-glucuronide in urine was not correlated with the age or sex of the individuals. Our results indicate that biotransformation of MeIQx via CYP1A2 oxidation to form the N-hydroxylamine followed by N2-glucuronidation is a general pathway of MeIQx metabolism in humans; the variability in the excreted levels of N-OH-MeIQx-N2-glucuronide is probably due to interindividual differences in UDP-glucuronosyltransferase activity and/or excretion pathways." @default.
• W1659189991 created "2016-06-24" @default.
• W1659189991 creator A5043108427 @default.
• W1659189991 creator A5084125220 @default.
• W1659189991 creator A5085112017 @default.
• W1659189991 creator A5088589795 @default.
• W1659189991 date "1999-10-15" @default.
• W1659189991 modified "2023-10-17" @default.
• W1659189991 title "N-oxidative metabolism of 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline (MeIQx) in humans: excretion of the N2-glucuronide conjugate of 2-hydroxyamino-MeIQx in urine." @default.
• W1659189991 cites W1495525337 @default.
• W1659189991 cites W1537734141 @default.
• W1659189991 cites W1542003118 @default.
• W1659189991 cites W1687198867 @default.
• W1659189991 cites W1976720273 @default.
• W1659189991 cites W1979497965 @default.
• W1659189991 cites W1982100187 @default.
• W1659189991 cites W1984603505 @default.
• W1659189991 cites W1985232100 @default.
• W1659189991 cites W1989692538 @default.
• W1659189991 cites W1989876710 @default.
• W1659189991 cites W1993780682 @default.
• W1659189991 cites W2005403824 @default.
• W1659189991 cites W2014352349 @default.
• W1659189991 cites W2016335393 @default.
• W1659189991 cites W2026550655 @default.
• W1659189991 cites W2034296822 @default.
• W1659189991 cites W2037276435 @default.
• W1659189991 cites W2045414214 @default.
• W1659189991 cites W2050189425 @default.
• W1659189991 cites W2055464779 @default.
• W1659189991 cites W2057561949 @default.
• W1659189991 cites W2059491405 @default.
• W1659189991 cites W2074512495 @default.
• W1659189991 cites W2080568192 @default.
• W1659189991 cites W2083841608 @default.
• W1659189991 cites W2091373506 @default.
• W1659189991 cites W2092959529 @default.
• W1659189991 cites W2127321206 @default.
• W1659189991 cites W2142080299 @default.
• W1659189991 cites W2164968031 @default.
• W1659189991 cites W2166468876 @default.
• W1659189991 cites W2168799076 @default.
• W1659189991 cites W2182920238 @default.
• W1659189991 cites W2185468658 @default.
• W1659189991 cites W2188170685 @default.
• W1659189991 cites W2210000121 @default.
• W1659189991 cites W2410208721 @default.
• W1659189991 cites W2395803699 @default.
• W1659189991 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10537291" @default.
• W1659189991 hasPublicationYear "1999" @default.
• W1659189991 type Work @default.
• W1659189991 sameAs 1659189991 @default.
• W1659189991 citedByCount "7" @default.
• W1659189991 countsByYear W16591899912015 @default.
• W1659189991 countsByYear W16591899912017 @default.
• W1659189991 crossrefType "journal-article" @default.
• W1659189991 hasAuthorship W1659189991A5043108427 @default.
• W1659189991 hasAuthorship W1659189991A5084125220 @default.
• W1659189991 hasAuthorship W1659189991A5085112017 @default.
• W1659189991 hasAuthorship W1659189991A5088589795 @default.
• W1659189991 hasConcept C114246631 @default.
• W1659189991 hasConcept C178790620 @default.
• W1659189991 hasConcept C181199279 @default.
• W1659189991 hasConcept C185592680 @default.
• W1659189991 hasConcept C2779186261 @default.
• W1659189991 hasConcept C2780026642 @default.
• W1659189991 hasConcept C2780362310 @default.
• W1659189991 hasConcept C2781109383 @default.
• W1659189991 hasConcept C27881333 @default.
• W1659189991 hasConcept C43617362 @default.
• W1659189991 hasConcept C526171541 @default.
• W1659189991 hasConcept C55493867 @default.
• W1659189991 hasConcept C62231903 @default.
• W1659189991 hasConcept C86745063 @default.
• W1659189991 hasConceptScore W1659189991C114246631 @default.
• W1659189991 hasConceptScore W1659189991C178790620 @default.
• W1659189991 hasConceptScore W1659189991C181199279 @default.
• W1659189991 hasConceptScore W1659189991C185592680 @default.
• W1659189991 hasConceptScore W1659189991C2779186261 @default.
• W1659189991 hasConceptScore W1659189991C2780026642 @default.
• W1659189991 hasConceptScore W1659189991C2780362310 @default.
• W1659189991 hasConceptScore W1659189991C2781109383 @default.
• W1659189991 hasConceptScore W1659189991C27881333 @default.
• W1659189991 hasConceptScore W1659189991C43617362 @default.
• W1659189991 hasConceptScore W1659189991C526171541 @default.
• W1659189991 hasConceptScore W1659189991C55493867 @default.
• W1659189991 hasConceptScore W1659189991C62231903 @default.
• W1659189991 hasConceptScore W1659189991C86745063 @default.
• W1659189991 hasIssue "20" @default.
• W1659189991 hasLocation W16591899911 @default.
• W1659189991 hasOpenAccess W1659189991 @default.
• W1659189991 hasPrimaryLocation W16591899911 @default.
• W1659189991 hasRelatedWork W2002416066 @default.
• W1659189991 hasRelatedWork W2002828889 @default.
• W1659189991 hasRelatedWork W2011694261 @default.
• W1659189991 hasRelatedWork W2030170670 @default.
• W1659189991 hasRelatedWork W2034296822 @default.
• W1659189991 hasRelatedWork W2054792420 @default.

• next