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• W165945008 abstract "This article examines some of the evidence for or against the hypothesis that guanosine 3′,5′-cyelic monophosphate (cGMP) is the intracellular mediator of the actions of acetylcholine (ACh), with particular emphasis on the situation in the mammalian nervous system. This idea arose following the widespread acceptance of a parallel role of adenosine 3′, 5′-cyclic monophosphate (cAMP) as the intracellular mediator of catecholaminergic (especially ß-receptor) activation (32). It was first put forward by George et al. (8) when they observed a correlation between the depressant effects of ACh on the rat heart and its cGMP content; and it was enthusiastically adopted and promoted by Greengard and his collaborators (11, 12, 20). The possibility that, in a variety of tissues, cAMP and cGMP systematically act in opposite fashion, thus providing the mechanism for “bidirectional” control of intracellular processes, has been much discussed (9, 10).KeywordsKainic AcidcGMP LevelCyclic MonophosphateIntracellular MediatorMammalian Nervous SystemThese keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves." @default.
• W165945008 created "2016-06-24" @default.
• W165945008 creator A5055716619 @default.
• W165945008 date "1978-01-01" @default.
• W165945008 modified "2023-10-02" @default.
• W165945008 title "Acetylcholine and Cyclic GMP" @default.
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• W165945008 doi "https://doi.org/10.1007/978-1-4684-3096-7_19" @default.
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