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- W1659696094 abstract "Abstract A procedure was developed to detect Dane particle-associated HB c Ag in blood of HB s Ag carriers with high titers of anti-HB c . Dane particles were separated from anti-HB c by gel filtration (Sepharose 4B) and centrifugation of the eluate through 20% (wt/ vol) sucrose at 40,000 rpm for 5 h, and the pellet was assayed for HB c Ag by a microtiter solid-phase radio-immunoassay (RIA). Despite a significant loss of antigenic activity throughout the procedure, the RIA for serum HB c Ag was a more sensitive and specific indicator of productive HBV infection than DNA polymerase assay of blood or 20-fold Dane particle concentrates from blood. HB c antigenemia correlated positively with HB c Ag in the liver by immunofluorescence and prevailed in patients with chronic hepatitis of the aggressive and persistent type; HB s Ag membrane fluorescence was prominent in the liver of patients with high serum concentrations of HB c Ag. HB c antigenemia was undetectable in 7 patients with chronic hepatitis and HB c Ag in the liver. This finding and lack of correlation between the amount of HB c Ag expressed in the liver and that circulating in the blood, indicates that under circumstances related to development of chronic liver disease, HB antigens synthetized in the liver may not be released into the blood. A negative serum HB c Ag by RIA is of limited clinical value, but a positive test is significant and can provide useful information on synthesis of HB c Ag in the absence of a liver biopsy data." @default.
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- W1659696094 date "1981-06-01" @default.
- W1659696094 modified "2023-09-24" @default.
- W1659696094 title "A radioimmunoassay for HBcAg in the sera of HBsAg carriers: Serum HBcAg, serum DNA polymerase activity, and liver HBcAg immunofluorescence as markers of chronic liver disease" @default.
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- W1659696094 doi "https://doi.org/10.1016/0016-5085(81)90252-3" @default.
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