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• W1660541928 abstract "Autoimmune and allergic diseases are major causes of morbidity. Antigen-based immunotherapy (AIT) is immunologically the most satisfying means of specifically targeting only those T cells driving disease, thereby inducing antigen-specific immune tolerance, with the lowest adverse risk profile. AIT is highly effective in rodent models of T cell-driven inflammation and is now in clinical trials. The range of approaches to applying AIT in the clinic prevents a consensus on the molecular basis for this form of tolerance. In particular, there has been a paucity of information on how pre-activated effector and memory T cells respond to AIT. New, advanced murine models of AIT are beginning to deliver such information at the cellular, biochemical, transcriptional and epigenetic levels." @default.
• W1660541928 created "2016-06-24" @default.
• W1660541928 creator A5048814583 @default.
• W1660541928 creator A5056546605 @default.
• W1660541928 date "2015-08-01" @default.
• W1660541928 modified "2023-09-23" @default.
• W1660541928 title "Antigen-based immunotherapy (AIT) for autoimmune and allergic disease" @default.
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• W1660541928 doi "https://doi.org/10.1016/j.coph.2015.05.003" @default.
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