Matches in SemOpenAlex for { <https://semopenalex.org/work/W1660818112> ?p ?o ?g. }
- W1660818112 endingPage "7689" @default.
- W1660818112 startingPage "7681" @default.
- W1660818112 abstract "Abstract Dok-4 (downstream of tyrosine kinase-4) is a recently identified member of the Dok family of adaptor proteins, which are characterized by an amino-terminal pleckstrin homology domain, a phosphotyrosine-binding domain, and a carboxyl-terminal region containing several tyrosines and poly-proline-rich motifs. Two members of the Dok family, Dok-1 and Dok-2, have already been described as negative regulators in T cells. However, the function of Dok-4, which is also expressed in T cells, remains unknown. In this study, we report that Dok-4 is phosphorylated after TCR engagement and shuttled within the cytoplasm of T cells before being recruited to the polarized microtubule organizing center after the formation of the immunological synapse. Loss-of-function experiments using RNA interference constructs show that Dok-4 is a negative regulator of ERK phosphorylation, IL-2 promoter activity, and T cell proliferation. Exogenous expression of wild-type Dok-4 induces a significant activation of Rap1, which is involved in the regulation of ERK. The pleckstrin homology domain of Dok-4 is required both for its cytoplasmic shuttling and relocalization as well as for its inhibitory properties on T cell activation. Thus, Dok-4 represents a novel negative regulator of T cells." @default.
- W1660818112 created "2016-06-24" @default.
- W1660818112 creator A5001052202 @default.
- W1660818112 creator A5010488274 @default.
- W1660818112 creator A5011774712 @default.
- W1660818112 creator A5015244527 @default.
- W1660818112 creator A5024023421 @default.
- W1660818112 creator A5029679351 @default.
- W1660818112 creator A5031511587 @default.
- W1660818112 creator A5038873652 @default.
- W1660818112 creator A5061432370 @default.
- W1660818112 date "2009-06-15" @default.
- W1660818112 modified "2023-09-30" @default.
- W1660818112 title "Dok-4 Is a Novel Negative Regulator of T Cell Activation" @default.
- W1660818112 cites W1507317291 @default.
- W1660818112 cites W1532445586 @default.
- W1660818112 cites W1533884439 @default.
- W1660818112 cites W1626003052 @default.
- W1660818112 cites W1967352670 @default.
- W1660818112 cites W1970329583 @default.
- W1660818112 cites W1973755084 @default.
- W1660818112 cites W1975910030 @default.
- W1660818112 cites W1979326892 @default.
- W1660818112 cites W1983205973 @default.
- W1660818112 cites W1984708316 @default.
- W1660818112 cites W1990883677 @default.
- W1660818112 cites W1995684205 @default.
- W1660818112 cites W2001640037 @default.
- W1660818112 cites W2007727729 @default.
- W1660818112 cites W2012083512 @default.
- W1660818112 cites W2018218393 @default.
- W1660818112 cites W2021599875 @default.
- W1660818112 cites W2022594276 @default.
- W1660818112 cites W2023276714 @default.
- W1660818112 cites W2029354255 @default.
- W1660818112 cites W2038641650 @default.
- W1660818112 cites W2038783205 @default.
- W1660818112 cites W2040063654 @default.
- W1660818112 cites W2043538721 @default.
- W1660818112 cites W2045735650 @default.
- W1660818112 cites W2051311262 @default.
- W1660818112 cites W2062497620 @default.
- W1660818112 cites W2066195224 @default.
- W1660818112 cites W2068832660 @default.
- W1660818112 cites W2070082950 @default.
- W1660818112 cites W2074049880 @default.
- W1660818112 cites W2075645766 @default.
- W1660818112 cites W2096234619 @default.
- W1660818112 cites W2118399632 @default.
- W1660818112 cites W2128686747 @default.
- W1660818112 cites W2129013406 @default.
- W1660818112 cites W2137994842 @default.
- W1660818112 cites W2149650496 @default.
- W1660818112 cites W2152093499 @default.
- W1660818112 cites W2152847526 @default.
- W1660818112 cites W2154230667 @default.
- W1660818112 cites W2160953520 @default.
- W1660818112 cites W2163468113 @default.
- W1660818112 doi "https://doi.org/10.4049/jimmunol.0802203" @default.
- W1660818112 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2814325" @default.
- W1660818112 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19494292" @default.
- W1660818112 hasPublicationYear "2009" @default.
- W1660818112 type Work @default.
- W1660818112 sameAs 1660818112 @default.
- W1660818112 citedByCount "19" @default.
- W1660818112 countsByYear W16608181122012 @default.
- W1660818112 countsByYear W16608181122013 @default.
- W1660818112 countsByYear W16608181122014 @default.
- W1660818112 countsByYear W16608181122015 @default.
- W1660818112 countsByYear W16608181122017 @default.
- W1660818112 countsByYear W16608181122018 @default.
- W1660818112 countsByYear W16608181122019 @default.
- W1660818112 countsByYear W16608181122022 @default.
- W1660818112 countsByYear W16608181122023 @default.
- W1660818112 crossrefType "journal-article" @default.
- W1660818112 hasAuthorship W1660818112A5001052202 @default.
- W1660818112 hasAuthorship W1660818112A5010488274 @default.
- W1660818112 hasAuthorship W1660818112A5011774712 @default.
- W1660818112 hasAuthorship W1660818112A5015244527 @default.
- W1660818112 hasAuthorship W1660818112A5024023421 @default.
- W1660818112 hasAuthorship W1660818112A5029679351 @default.
- W1660818112 hasAuthorship W1660818112A5031511587 @default.
- W1660818112 hasAuthorship W1660818112A5038873652 @default.
- W1660818112 hasAuthorship W1660818112A5061432370 @default.
- W1660818112 hasBestOaLocation W16608181121 @default.
- W1660818112 hasConcept C104317684 @default.
- W1660818112 hasConcept C11960822 @default.
- W1660818112 hasConcept C153911025 @default.
- W1660818112 hasConcept C179464577 @default.
- W1660818112 hasConcept C183786373 @default.
- W1660818112 hasConcept C190062978 @default.
- W1660818112 hasConcept C2776090121 @default.
- W1660818112 hasConcept C49658373 @default.
- W1660818112 hasConcept C54355233 @default.
- W1660818112 hasConcept C55493867 @default.
- W1660818112 hasConcept C57074206 @default.
- W1660818112 hasConcept C6929976 @default.
- W1660818112 hasConcept C86803240 @default.