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- W166089720 abstract "This chapter discusses some consequences of inhibition of the de novo pathway of pyrimidtne biosynthesis. Inhibition of pyrimidine synthesis de novo has been accomplished by a variety of analogs. One of these agents, 6-azauridine, exhibited a modest degree of antineoplastic and antiviral activity. The chapter also presents some perspective on the effects of these agents in tumor bearing animals as it may relate to their demonstrable biochemical effects. The chapter also discusses the potential for combination therapy with inhibitors that deplete the pools of pyrimidine nucleotides and analogs that are activated by the salvage pathways are apparent. From such studies, an unexpected interaction with allopurinol has come that has the potential for increasing the selective toxicity of 5-fluorouracil for tumor cells. A more direct approach to effects at the tissue level has been the measurement of cellular accumulation of orotate and orotidine caused by a single dose of pyrazofurin after one or three days treatment with PALA at very large doses." @default.
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- W166089720 date "1979-01-01" @default.
- W166089720 modified "2023-10-18" @default.
- W166089720 title "SOME CONSEQUENCES OF INHIBITION OF THE DE NOVO PATHWAY OF PYRIMIDINE BIOSYNTHESIS" @default.
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- W166089720 doi "https://doi.org/10.1016/b978-0-08-024384-9.50028-2" @default.
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