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• W166125812 abstract "Hepatitis C virus (HCV) frequently causes chronic hepatitis, cirrhosis and hepatocellular carcinoma (CHOO et al. 1989; KUO et al. 1989; OHKOSHI et al. 1990; SAITO et al. 1990). HCV is considered to belong to the family Flaviviridae, whose members have a positive-stranded RNA genome of about 9.6kb including a large open reading frame (ORF). The ORF encodes a polyprotein precursor of about 3,000 amino acids (KATO et al. 1990; TANAKA et al. 1995), subsequently cleaved into at least 11 structural and nonstructural viral proteins (HIJIKATA et al. 1991a, 1993a,b). Although our understanding of the molecular biology of HCV has progressed rapidly (reviewed by SHIMOTOHNO 1995; HOUGHTON 1996, RICE 1996, SHIMOTOHNO and FEINSTONE 1997; MAJOR and FEINSTONE 1997), all the data regarding the functions of HCV gene products have been obtained in artificial systems, either in vitro or in vivo, using established mammalian cell expression systems. Therefore, these dataneed to be confirmed in HCV-infected cells. Unfortunately, to data, no satisfactory tissue culture system has been developed in which HCV can be multiplied to the extent required for such experiments. However, several trials for the establishment of HCV replication and multiplication system using mammalian cultured cells have been performed. In this review, we describe the recent results of studies using human lymphocytes and hepatocytes to propagate HCV." @default.
• W166125812 created "2016-06-24" @default.
• W166125812 creator A5041139736 @default.
• W166125812 creator A5089756486 @default.
• W166125812 date "2000-01-01" @default.
• W166125812 modified "2023-10-16" @default.
• W166125812 title "Systems to Culture Hepatitis C Virus" @default.
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• W166125812 doi "https://doi.org/10.1007/978-3-642-59605-6_12" @default.
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