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- W1661548638 endingPage "108" @default.
- W1661548638 startingPage "108" @default.
- W1661548638 abstract "Type 1 and type 2 diabetic patients are at increased risk of cardiomyopathy and heart failure is a major cause of death for these patients. Cardiomyopathy in diabetes is associated with a cluster of features including decreased diastolic compliance, interstitial fibrosis and myocyte hypertrophy. The mechanisms leading to diabetic cardiomyopathy remain uncertain. Diabetes is associated with most known risk factors for cardiac failure seen in the overall population, including obesity, dyslipidemia, thrombosis, infarction, hypertension, activation of multiple hormone and cytokine systems, autonomic neuropathy, endothelial dysfunction and coronary artery disease. In light of these common contributing pathologies it remains uncertain whether diabetic cardiomyopathy is a distinct disease. It is also uncertain which factors are most important to the overall incidence of heart failure in diabetic patients. This review focuses on factors that can have direct effects on diabetic cardiomyocytes: hyperglycemia, altered fuel use, and changes in the activity of insulin and angiotensin. Particular attention is given to the changes these factors can have on cardiac mitochondria and the role of reactive oxygen species in mediating injury to cardiomyocytes." @default.
- W1661548638 created "2016-06-24" @default.
- W1661548638 creator A5005039651 @default.
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- W1661548638 creator A5037156658 @default.
- W1661548638 creator A5065749286 @default.
- W1661548638 creator A5085043351 @default.
- W1661548638 date "2006-01-01" @default.
- W1661548638 modified "2023-10-17" @default.
- W1661548638 title "Causes and Characteristics of Diabetic Cardiomyopathy" @default.
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- W1661548638 doi "https://doi.org/10.1900/rds.2006.3.108" @default.
- W1661548638 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1783586" @default.
- W1661548638 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17487334" @default.
- W1661548638 hasPublicationYear "2006" @default.