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- W166158768 abstract "Brown adipose tissue is the main site of nonshivering thermogenesis. Its heat-producing function is utilized during arousal from hibernation, during acclimation to cold, during the neonatal period, and during diet-induced thermogenesis. Chemical energy is dissipated as heat in the mitochondria, where the unique uncoupling protein works as a proton shunt (Cannon and Nedergaard, 1985; Trayhurn and Nicholls, 1986). The organ is well vascularized and innervated; brown adipocytes both activate and maintain their extremely high metabolism due to adrenergic stimulation. This results in a characteristic three-phase change in the cell membrane potential; first, a relatively rapid 25 mV depolarization lasting 10–30 s, then a repolarization with a 5–10 mV hyperpolariza-tion lasting 2–5 min and, finally, a 20–25 mV depolarization for as long as the adrenergic stimulation continues (Connolly et al., 1989; Horwitz et al., 1989; Lucero and Pappone, 1990). The initial depolarization is due mainly to a,-adrenergic stimulation and is probably caused by Cl-efflux through 40 pS Cl--channels (Dasso et al., 1990; Sabanov et al., 1993). The hyperpolarization is activated by mainly α 1- and perhaps by β -adrenergic agonists and is mediated by voltage-gated and Ca2+-activated K+-channels (Nânberg et al., 1985; Lucero and Pappone, 1989, 1990)." @default.
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- W166158768 date "1993-01-01" @default.
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- W166158768 title "Nonselective Cation Channels in Brown and White Fat Cells" @default.
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- W166158768 doi "https://doi.org/10.1007/978-3-0348-7327-7_15" @default.
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