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W1661636224 abstract "Twenty-three patients with Stage III, Stage IV, or recurrent epithelial ovarian cancer were treated with a combination of melphalan and levamisole to determine a tolerable dosage schedule, possible adverse effects, and a general estimate of response rate and duration. In seven patients with measurable disease there were four complete responses (57%) with a median duration of 75 weeks. Two of the complete responders have had negative second-look laparotomies while the other two patients have had subsequent progression. Of 16 patients with nonmeasurable disease two have had negative second-look laparotomies and two remain progression free. Thus 8 of 23 patients (35%) had complete responses or remain progression free whereas 4 of 23 patients (17%) have had negative second-look laparotomies. No serious toxicity was encountered. Immunologic monitoring did not indicate significant immunologic reconstitution in these immunosuppressed patients." @default.
W1661636224 created "2016-06-24" @default.
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W1661636224 date "1981-09-01" @default.
W1661636224 modified "2023-09-26" @default.
W1661636224 title "Chemotherapy of advanced ovarian epithelial carcinoma with melphalan and levamisole: A pilot study of the Gynecologic Oncology Group" @default.
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W1661636224 doi "https://doi.org/10.1016/0002-9378(81)90676-1" @default.
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