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- W1661726757 endingPage "1840" @default.
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- W1661726757 abstract "The axon initial segment (AIS) contains the site of action potential initiation and plays a major role in neuronal excitability. AIS function relies on high concentrations of different ion channels and complex regulatory mechanisms that orchestrate molecular microarchitecture. We review recent evidence that a large number of ion channels associated with epilepsy are enriched at the AIS, making it a ‘hotspot’ for epileptogenesis. Furthermore, we present novel data on the clustering of GABRγ2 receptors in the AIS of cortical and hippocampal neurons in a knock in mouse model of a human genetic epilepsy. This article highlights the molecular coincidence of epilepsy mutations at the AIS and reviews pathogenic mechanisms converging at the AIS." @default.
- W1661726757 created "2016-06-24" @default.
- W1661726757 creator A5042797282 @default.
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- W1661726757 date "2010-05-28" @default.
- W1661726757 modified "2023-09-26" @default.
- W1661726757 title "Axon initial segment dysfunction in epilepsy" @default.
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