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• W1661761832 abstract "The inositol 1,4,5-trisphosphate receptor (InsP3R) is the main calcium(Ca2+) release channel in most tissues. Three isoforms have been identified1,2,3,4,5,6, but only types I and II InsP3R have been characterized7,8. Here we examine the functional properties of the type III InsP3R because this receptor is restricted to the trigger zone from which Ca2+ waves originate9,10,11 and it has distinctive InsP3-binding properties12,13. We find that type III InsP3R forms Ca2+ channels with single-channel currents that are similar to those of type I InsP3R; however, the open probability of type III InsP3R isoform increases monotonically with increased cytoplasmic Ca2+ concentration, whereas the type I isoform has a bell-shaped dependence on cytoplasmic Ca2+. The properties of type III InsP3R provide positive feedback as Ca2+ is released; the lack of negative feedback allows complete Ca2+ release from intracellular stores. Thus, activation of type III InsP3R in cells that express only this isoform results in a single transient, but global, increase in the concentration of cytosolic Ca2+. The bell-shaped Ca2+-dependence curve of type I InsP3R is ideal for supporting Ca2+ oscillations, whereas the properties of type III InsP3R are better suited to signal initiation." @default.
• W1661761832 created "2016-06-24" @default.
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• W1661761832 date "1998-11-01" @default.
• W1661761832 modified "2023-10-15" @default.
• W1661761832 title "Type III InsP3 receptor channel stays open in the presence of increased calcium" @default.
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• W1661761832 doi "https://doi.org/10.1038/23954" @default.
• W1661761832 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2825878" @default.
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