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- W16620575 abstract "Coronary heart disease (CHD) is a major contributor of mortality and morbidity in the modern world and frequently develops into myocardial infarction (MI). The ischemic injury that characterizes MI is followed by an orchestrated, but highly heterogeneous, chain of events, in which the inflammatory response plays a pivotal role. The activation of the immune response is essential for the normal wound healing, a process that aims to replace the injured myocardial tissue following injury. Multiple cellular and molecular signals contribute vital functions throughout this process, the spatial and temporal aspects of which are tightly regulated. Inadequate or exaggerated response to inflammation can lead to adverse remodeling with devastating effects for the injured heart. Given the exceptional pathophysiologic complexity of the systems regulating the inflammatory response during atherogenesis and during the early wound healing following MI, several factors need to be considered in the quest for the optimal treatment. Furthermore, the currently available therapeutic arsenal targets—directly and indirectly—the inflammatory response; however, it is far from being regarded as adequate. Novel pharmacotherapeutic strategies are urgently needed in order to drastically reduce the burden of CHD. This chapter discusses the general concepts of atherosclerosis, which eventually lead to MI, and of the post-MI wound-healing process with special focus on the inflammatory components (cellular and molecular) that play decisive roles in the immune response as well as the current and innovative therapies in the field." @default.
- W16620575 created "2016-06-24" @default.
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- W16620575 date "2015-01-01" @default.
- W16620575 modified "2023-09-27" @default.
- W16620575 title "The Role of Inflammation in Myocardial Infarction" @default.
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