Matches in SemOpenAlex for { <https://semopenalex.org/work/W1662284013> ?p ?o ?g. }
Showing items 1 to 78 of
78
with 100 items per page.
- W1662284013 endingPage "3710" @default.
- W1662284013 startingPage "3704" @default.
- W1662284013 abstract "Mouse helper T cell lines were developed that proliferate permanently without Ag and APCs in response to either IL-2, IL-4, or IL-9, three cytokines whose receptors interact with the IL-2R gamma-chain for signal transduction. Depending on the growth factor, a marked difference was observed regarding the ability of dexamethasone (DEX) to inhibit cell proliferation. In three different cell lines, proliferation induced by IL-2 was completely arrested, while that supported by IL-9 was hardly affected. With IL-4, proliferation was also maintained but less markedly than with IL-9. Although DEX was able to induce apoptosis in these cells, the inhibition of IL-2-induced proliferation was not the result of apoptosis, as this process was equally antagonized by all three factors. Moreover, addition of IL-4 or IL-9 to cultures previously incubated with IL-2 and DEX for several days restored cell proliferation. Finally, autonomous cell variants derived from the factor-dependent cell lines were still protected by IL-4 and IL-9 against growth inhibition by DEX. Together, these results indicate that growth stimulation in the presence of glucocorticoids and inhibition of apoptosis involve distinct aspects of cytokine activities." @default.
- W1662284013 created "2016-06-24" @default.
- W1662284013 creator A5021028530 @default.
- W1662284013 creator A5036695915 @default.
- W1662284013 creator A5037139062 @default.
- W1662284013 creator A5075587189 @default.
- W1662284013 creator A5077643515 @default.
- W1662284013 creator A5084739619 @default.
- W1662284013 creator A5087838405 @default.
- W1662284013 date "1996-05-15" @default.
- W1662284013 modified "2023-10-10" @default.
- W1662284013 title "Differential activity of dexamethasone on IL-2-, IL-4-, or IL-9-induced proliferation of murine factor-dependent T cell lines." @default.
- W1662284013 doi "https://doi.org/10.4049/jimmunol.156.10.3704" @default.
- W1662284013 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8621905" @default.
- W1662284013 hasPublicationYear "1996" @default.
- W1662284013 type Work @default.
- W1662284013 sameAs 1662284013 @default.
- W1662284013 citedByCount "20" @default.
- W1662284013 countsByYear W16622840132013 @default.
- W1662284013 crossrefType "journal-article" @default.
- W1662284013 hasAuthorship W1662284013A5021028530 @default.
- W1662284013 hasAuthorship W1662284013A5036695915 @default.
- W1662284013 hasAuthorship W1662284013A5037139062 @default.
- W1662284013 hasAuthorship W1662284013A5075587189 @default.
- W1662284013 hasAuthorship W1662284013A5077643515 @default.
- W1662284013 hasAuthorship W1662284013A5084739619 @default.
- W1662284013 hasAuthorship W1662284013A5087838405 @default.
- W1662284013 hasBestOaLocation W16622840131 @default.
- W1662284013 hasConcept C134018914 @default.
- W1662284013 hasConcept C170493617 @default.
- W1662284013 hasConcept C190283241 @default.
- W1662284013 hasConcept C203014093 @default.
- W1662284013 hasConcept C24998067 @default.
- W1662284013 hasConcept C2778690821 @default.
- W1662284013 hasConcept C2780401358 @default.
- W1662284013 hasConcept C54355233 @default.
- W1662284013 hasConcept C55493867 @default.
- W1662284013 hasConcept C62112901 @default.
- W1662284013 hasConcept C62478195 @default.
- W1662284013 hasConcept C81885089 @default.
- W1662284013 hasConcept C86803240 @default.
- W1662284013 hasConcept C95444343 @default.
- W1662284013 hasConceptScore W1662284013C134018914 @default.
- W1662284013 hasConceptScore W1662284013C170493617 @default.
- W1662284013 hasConceptScore W1662284013C190283241 @default.
- W1662284013 hasConceptScore W1662284013C203014093 @default.
- W1662284013 hasConceptScore W1662284013C24998067 @default.
- W1662284013 hasConceptScore W1662284013C2778690821 @default.
- W1662284013 hasConceptScore W1662284013C2780401358 @default.
- W1662284013 hasConceptScore W1662284013C54355233 @default.
- W1662284013 hasConceptScore W1662284013C55493867 @default.
- W1662284013 hasConceptScore W1662284013C62112901 @default.
- W1662284013 hasConceptScore W1662284013C62478195 @default.
- W1662284013 hasConceptScore W1662284013C81885089 @default.
- W1662284013 hasConceptScore W1662284013C86803240 @default.
- W1662284013 hasConceptScore W1662284013C95444343 @default.
- W1662284013 hasIssue "10" @default.
- W1662284013 hasLocation W16622840131 @default.
- W1662284013 hasLocation W16622840132 @default.
- W1662284013 hasOpenAccess W1662284013 @default.
- W1662284013 hasPrimaryLocation W16622840131 @default.
- W1662284013 hasRelatedWork W2049264678 @default.
- W1662284013 hasRelatedWork W2147761319 @default.
- W1662284013 hasRelatedWork W2355259601 @default.
- W1662284013 hasRelatedWork W2374945858 @default.
- W1662284013 hasRelatedWork W2403149556 @default.
- W1662284013 hasRelatedWork W2403499974 @default.
- W1662284013 hasRelatedWork W2745882536 @default.
- W1662284013 hasRelatedWork W3183408539 @default.
- W1662284013 hasRelatedWork W32932267 @default.
- W1662284013 hasRelatedWork W4210933432 @default.
- W1662284013 hasVolume "156" @default.
- W1662284013 isParatext "false" @default.
- W1662284013 isRetracted "false" @default.
- W1662284013 magId "1662284013" @default.
- W1662284013 workType "article" @default.