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• W166235353 endingPage "144" @default.
• W166235353 startingPage "125" @default.
• W166235353 abstract "The complex process by which a multicellular organ, such as the human being, acquires the energy needed for life has been shaped by the evolutionary transition from a single-cell organism, which survived primarily by unlimited cell proliferation in an ever-changing oxygen-environment, using glycolysis. The transition to a multicellular state occurred in an oxygenated environment, which necessitated the development of a mitochondrial oxidative phosphorylation process and concomitant acquisition of new genotypes and phenotypes, including (1) the creation of germinal and somatic organ-specific adult stem cells; (2) their oxygen-protecting niches; (3) the ability to adaptively regulate symmetrical and asymmetrical cell division for either stem cell expansion or the differentiation of multiple cell types; (4) apoptosis; and (5) cellular senescence. Both endogenous and exogenous environmental and nutritional/dietary factors that can affect the quality and quantity of stem cells during embryonic/fetal development can alter the risk of stem cell-based diseases, such as cancer, later in life (the Barker hypothesis). Fundamental to both aging and the diseases of aging is the role of oxidative stress, which induces intracellular signaling and is critical to the behavioral choices that stem cells and life span-limited differentiated cells must make. It is here that oxidative stress-induced inflammatory processes can induce secreted factors that can affect multiple responses, i.e. proliferation, differentiation, apoptosis, in normal and initiated adult stem cells, normal progenitor, and terminally differentiated cells. It is here, also, where the nutritional status, directed by diet and exercise, can modulate (increase or decrease) the factors that can trigger oxidative stress-induced signaling in either the immune and other organ systems. In other words, these nutritional/dietary factors can either contribute to or protect against various inflammatory-related diseases." @default.
• W166235353 created "2016-06-24" @default.
• W166235353 creator A5001846206 @default.
• W166235353 creator A5039475649 @default.
• W166235353 creator A5044183156 @default.
• W166235353 creator A5066140568 @default.
• W166235353 date "2014-01-01" @default.
• W166235353 modified "2023-09-26" @default.
• W166235353 title "Diet/Nutrition, Inflammation, Cellular Senescence, Stem Cells, Diseases of Aging, and Aging" @default.
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