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- W166257218 abstract "Research Article1 February 1985free access Analogue inhibitor of 2-5A action: effect on the interferon-mediated inhibition of encephalomyocarditis virus replication. D. Watling D. Watling Search for more papers by this author H.T. Serafinowska H.T. Serafinowska Search for more papers by this author C.B. Reese C.B. Reese Search for more papers by this author I.M. Kerr I.M. Kerr Search for more papers by this author D. Watling D. Watling Search for more papers by this author H.T. Serafinowska H.T. Serafinowska Search for more papers by this author C.B. Reese C.B. Reese Search for more papers by this author I.M. Kerr I.M. Kerr Search for more papers by this author Author Information D. Watling, H.T. Serafinowska, C.B. Reese and I.M. Kerr The EMBO Journal (1985)4:431-436https://doi.org/10.1002/j.1460-2075.1985.tb03647.x PDFDownload PDF of article text and main figures. ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinked InMendeleyWechatReddit Figures & Info Chemically synthesised CH3Sp(A2′p)2A2′pp3′OCH3 has been used to assess the importance of the ppp(A2′p)nA (n greater than or equal to 2: 2-5A) system in the antiviral action of interferon against encephalomyocarditis virus (EMC). It inhibits activation of the 2-5A-dependent RNase by 2-5A in intact mouse L929 cells and cell-free systems. In interferon-treated, EMC-infected L929 cells it inhibits 2-5A-mediated rRNA cleavage and partially restores EMC RNA synthesis and virus yield. Activation of the 2-5A-dependent RNase must, therefore, play some part in interferon action against the growth of EMC virus in such cells. Previous ArticleNext Article Volume 4Issue 21 February 1985In this issue RelatedDetailsLoading ..." @default.
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- W166257218 title "Analogue inhibitor of 2-5A action: effect on the interferon-mediated inhibition of encephalomyocarditis virus replication." @default.
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