Matches in SemOpenAlex for { <https://semopenalex.org/work/W1662779407> ?p ?o ?g. }
- W1662779407 endingPage "347" @default.
- W1662779407 startingPage "325" @default.
- W1662779407 abstract "Reproductive function is tightly regulated by an intricate network of central and peripheral factors; however, the precise mechanism triggering critical reproductive events, such as puberty onset, remains largely unknown. Recently, the neuropeptides kisspeptin (encoded by Kiss1) and neurokinin B (NKB, encoded by TAC3 in humans and Tac2 in rodents) have been placed as essential gatekeepers of puberty. Studies in humans and rodents have revealed that loss-of-function mutations in the genes encoding either kisspeptin and NKB or their receptors, Kiss1r and neurokinin 3 receptor (NK3R), lead to impaired sexual maturation and infertility. Kisspeptin, NKB, and dynorphin A are co-expressed in neurons of the arcuate nucleus (ARC), so-called Kisspeptin/NKB/Dyn (KNDy) neurons. Importantly, these neurons also co-express NK3R. Compelling evidence suggests a stimulatory role of NKB (or the NK3R agonist, senktide) on LH release in a number of species. This effect is likely mediated by autosynaptic inputs of NKB on KNDy neurons to induce the secretion of gonadotropin-releasing hormone (GnRH) in a kisspeptin-dependent manner, with the coordinated actions of other neuroendocrine factors, such as dynorphin, glutamate, or GABA. Thus, we have proposed a model in which NKB feeds back to the KNDy neuron to shape the pulsatile release of kisspeptin, and hence GnRH, in a mechanism also dependent on the sex steroid level. Additionally, NKB may contribute to the regulation of the reproductive function by metabolic cues. Investigating how NKB and kisspeptin interact to regulate the gonadotropic axis will offer new insights into the control of GnRH release during puberty onset and the maintenance of the reproductive function in adulthood, offering a platform for the understanding and treatment of a number of reproductive disorders." @default.
- W1662779407 created "2016-06-24" @default.
- W1662779407 creator A5064566203 @default.
- W1662779407 date "2013-01-01" @default.
- W1662779407 modified "2023-10-18" @default.
- W1662779407 title "Interactions Between Kisspeptins and Neurokinin B" @default.
- W1662779407 cites W1489541636 @default.
- W1662779407 cites W1516950285 @default.
- W1662779407 cites W1574613661 @default.
- W1662779407 cites W1596559390 @default.
- W1662779407 cites W188792598 @default.
- W1662779407 cites W1964587473 @default.
- W1662779407 cites W1964637416 @default.
- W1662779407 cites W1972602091 @default.
- W1662779407 cites W1975594655 @default.
- W1662779407 cites W1975890243 @default.
- W1662779407 cites W1977013546 @default.
- W1662779407 cites W1977250427 @default.
- W1662779407 cites W1977865535 @default.
- W1662779407 cites W1977946309 @default.
- W1662779407 cites W1978664632 @default.
- W1662779407 cites W1979588495 @default.
- W1662779407 cites W1979964871 @default.
- W1662779407 cites W1980564487 @default.
- W1662779407 cites W1980839404 @default.
- W1662779407 cites W1981585384 @default.
- W1662779407 cites W1984935854 @default.
- W1662779407 cites W1986891718 @default.
- W1662779407 cites W1986943820 @default.
- W1662779407 cites W1987587343 @default.
- W1662779407 cites W1989797457 @default.
- W1662779407 cites W1990688781 @default.
- W1662779407 cites W1992174470 @default.
- W1662779407 cites W1994650442 @default.
- W1662779407 cites W1995639832 @default.
- W1662779407 cites W2004026274 @default.
- W1662779407 cites W2010844149 @default.
- W1662779407 cites W2010920434 @default.
- W1662779407 cites W2010939792 @default.
- W1662779407 cites W2011431600 @default.
- W1662779407 cites W2012785766 @default.
- W1662779407 cites W2012850984 @default.
- W1662779407 cites W2015392373 @default.
- W1662779407 cites W2016237494 @default.
- W1662779407 cites W2017374997 @default.
- W1662779407 cites W2019097241 @default.
- W1662779407 cites W2019501332 @default.
- W1662779407 cites W2021607587 @default.
- W1662779407 cites W2022160987 @default.
- W1662779407 cites W2022586856 @default.
- W1662779407 cites W2023793461 @default.
- W1662779407 cites W2023976238 @default.
- W1662779407 cites W2025295789 @default.
- W1662779407 cites W2025895459 @default.
- W1662779407 cites W2026612675 @default.
- W1662779407 cites W2026732159 @default.
- W1662779407 cites W2027617280 @default.
- W1662779407 cites W2027998184 @default.
- W1662779407 cites W2030025448 @default.
- W1662779407 cites W2030585597 @default.
- W1662779407 cites W2032659088 @default.
- W1662779407 cites W2032770360 @default.
- W1662779407 cites W2035681673 @default.
- W1662779407 cites W2035954641 @default.
- W1662779407 cites W2036074652 @default.
- W1662779407 cites W2036907328 @default.
- W1662779407 cites W2037346164 @default.
- W1662779407 cites W2039399283 @default.
- W1662779407 cites W2041165166 @default.
- W1662779407 cites W2041506924 @default.
- W1662779407 cites W2044556205 @default.
- W1662779407 cites W2045555035 @default.
- W1662779407 cites W2045601312 @default.
- W1662779407 cites W2045883535 @default.
- W1662779407 cites W2047994492 @default.
- W1662779407 cites W2048683024 @default.
- W1662779407 cites W2050874028 @default.
- W1662779407 cites W2051081976 @default.
- W1662779407 cites W2051396500 @default.
- W1662779407 cites W2053608443 @default.
- W1662779407 cites W2054212106 @default.
- W1662779407 cites W2056779380 @default.
- W1662779407 cites W2058324135 @default.
- W1662779407 cites W2059622696 @default.
- W1662779407 cites W2068426167 @default.
- W1662779407 cites W2069137752 @default.
- W1662779407 cites W2070138234 @default.
- W1662779407 cites W2072196971 @default.
- W1662779407 cites W2072513181 @default.
- W1662779407 cites W2073220855 @default.
- W1662779407 cites W2074635271 @default.
- W1662779407 cites W2076133996 @default.
- W1662779407 cites W2078172586 @default.
- W1662779407 cites W2088127056 @default.
- W1662779407 cites W2090473343 @default.
- W1662779407 cites W2091398724 @default.
- W1662779407 cites W2092614270 @default.
- W1662779407 cites W2098118160 @default.