Matches in SemOpenAlex for { <https://semopenalex.org/work/W1663199246> ?p ?o ?g. }
Showing items 1 to 90 of
90
with 100 items per page.
- W1663199246 endingPage "211" @default.
- W1663199246 startingPage "204" @default.
- W1663199246 abstract "Isolates of Bacillus subtilis that had been presumed to carry the cysA14 lesion have been studied. Our data indicate that these strains contain four mutations, all of which are linked by transformation and lie in the region of the ribosomal markers. The requirement for cysteine results from a defective serine transacetylase that is coded for by the cysA locus. Therefore, these mutants grow only in the presence of cysteine but not with sulfate, sulfite, or sulfide as the sole source of sulfur. A second genetic lesion (css) can be recognized by an increased sensitivity to the amino acid L-cysteine. The inhibited enzyme(s) has not been determined but inhibition is overcome by a mixture of eight amino acids. The third mutation (hts) results in the overproduction and excretion of hydrogen sulfide. This compound appears to be produced from cysteine by the enzyme cysteine desulfhydrylase and not by an increased activity of the sulfate-reductive pathway. This locus presumably codes for a regulatory element involved in the control of cysteine desulfhydrylase. The fourth mutation (cym) is not well characterized biochemically but results in a requirement for cysteine or methionine. The following order of these mutations has been established by transformation studies: hts, cysA, css, cym. The generally poor growth of these mutants in minimal-salts glucose media supplemented with cysteine can now be explained by these observations. The cysA14 mutants not only require an amino acid that is itself inhibitory to growth but they also overproduce the highly toxic compound hydrogen sulfide." @default.
- W1663199246 created "2016-06-24" @default.
- W1663199246 creator A5046782203 @default.
- W1663199246 creator A5084727537 @default.
- W1663199246 creator A5085373805 @default.
- W1663199246 date "1975-01-01" @default.
- W1663199246 modified "2023-09-25" @default.
- W1663199246 title "Multiple mutations in cysA 14 MUTANTS OF Bacillus subtilis" @default.
- W1663199246 cites W1017291046 @default.
- W1663199246 cites W1485892674 @default.
- W1663199246 cites W1488140460 @default.
- W1663199246 cites W1491231875 @default.
- W1663199246 cites W1499845280 @default.
- W1663199246 cites W173189030 @default.
- W1663199246 cites W1875444097 @default.
- W1663199246 cites W1976727869 @default.
- W1663199246 cites W1985320779 @default.
- W1663199246 cites W2006808232 @default.
- W1663199246 cites W2014102437 @default.
- W1663199246 cites W2025987130 @default.
- W1663199246 cites W2068940261 @default.
- W1663199246 cites W2216761442 @default.
- W1663199246 cites W2290557620 @default.
- W1663199246 cites W2410803051 @default.
- W1663199246 cites W241581505 @default.
- W1663199246 cites W2419243178 @default.
- W1663199246 doi "https://doi.org/10.1128/jb.121.1.204-211.1975" @default.
- W1663199246 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/285632" @default.
- W1663199246 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/803951" @default.
- W1663199246 hasPublicationYear "1975" @default.
- W1663199246 type Work @default.
- W1663199246 sameAs 1663199246 @default.
- W1663199246 citedByCount "15" @default.
- W1663199246 countsByYear W16631992462014 @default.
- W1663199246 crossrefType "journal-article" @default.
- W1663199246 hasAuthorship W1663199246A5046782203 @default.
- W1663199246 hasAuthorship W1663199246A5084727537 @default.
- W1663199246 hasAuthorship W1663199246A5085373805 @default.
- W1663199246 hasBestOaLocation W16631992461 @default.
- W1663199246 hasConcept C104317684 @default.
- W1663199246 hasConcept C143065580 @default.
- W1663199246 hasConcept C181199279 @default.
- W1663199246 hasConcept C20950039 @default.
- W1663199246 hasConcept C2776414213 @default.
- W1663199246 hasConcept C2777272437 @default.
- W1663199246 hasConcept C2779201268 @default.
- W1663199246 hasConcept C2780912031 @default.
- W1663199246 hasConcept C515207424 @default.
- W1663199246 hasConcept C523546767 @default.
- W1663199246 hasConcept C54355233 @default.
- W1663199246 hasConcept C55493867 @default.
- W1663199246 hasConcept C65192284 @default.
- W1663199246 hasConcept C86803240 @default.
- W1663199246 hasConceptScore W1663199246C104317684 @default.
- W1663199246 hasConceptScore W1663199246C143065580 @default.
- W1663199246 hasConceptScore W1663199246C181199279 @default.
- W1663199246 hasConceptScore W1663199246C20950039 @default.
- W1663199246 hasConceptScore W1663199246C2776414213 @default.
- W1663199246 hasConceptScore W1663199246C2777272437 @default.
- W1663199246 hasConceptScore W1663199246C2779201268 @default.
- W1663199246 hasConceptScore W1663199246C2780912031 @default.
- W1663199246 hasConceptScore W1663199246C515207424 @default.
- W1663199246 hasConceptScore W1663199246C523546767 @default.
- W1663199246 hasConceptScore W1663199246C54355233 @default.
- W1663199246 hasConceptScore W1663199246C55493867 @default.
- W1663199246 hasConceptScore W1663199246C65192284 @default.
- W1663199246 hasConceptScore W1663199246C86803240 @default.
- W1663199246 hasIssue "1" @default.
- W1663199246 hasLocation W16631992461 @default.
- W1663199246 hasLocation W16631992462 @default.
- W1663199246 hasLocation W16631992463 @default.
- W1663199246 hasOpenAccess W1663199246 @default.
- W1663199246 hasPrimaryLocation W16631992461 @default.
- W1663199246 hasRelatedWork W1663199246 @default.
- W1663199246 hasRelatedWork W1734654270 @default.
- W1663199246 hasRelatedWork W1909647962 @default.
- W1663199246 hasRelatedWork W2042971445 @default.
- W1663199246 hasRelatedWork W2063737743 @default.
- W1663199246 hasRelatedWork W2337563251 @default.
- W1663199246 hasRelatedWork W2416306772 @default.
- W1663199246 hasRelatedWork W2521109871 @default.
- W1663199246 hasRelatedWork W2805840248 @default.
- W1663199246 hasRelatedWork W4211021704 @default.
- W1663199246 hasVolume "121" @default.
- W1663199246 isParatext "false" @default.
- W1663199246 isRetracted "false" @default.
- W1663199246 magId "1663199246" @default.
- W1663199246 workType "article" @default.