Matches in SemOpenAlex for { <https://semopenalex.org/work/W1663640707> ?p ?o ?g. }
- W1663640707 endingPage "45" @default.
- W1663640707 startingPage "21" @default.
- W1663640707 abstract "The coxsackie-adenovirus receptor (CAR) is the prototype of a small subfamily of IgCAMs composed of CAR itself, CLMP, BT-IgSF, ESAM, CTX, and A33. These six proteins are composed of one V-set and one C2-set Ig domains and a single transmembrane helix followed by a cytoplasmic stretch. They are localized in several tissues and organs and - except for ESAM, CTX, and A33 - are expressed in the developing brain. CAR becomes downregulated at early postnatal stages and is absent from the adult brain. CAR, CLMP, and BT-IgSF mediate homotypic aggregation. Interestingly, cell adhesion experiments, binding studies, and crystallographic investigations on the extracellular domain reveal a flexible ectodomain for CAR that mediates homophilic and heterophilic binding.CAR has been extensively investigated in the context of gene therapy and diseases, while research on BT-IgSF and CLMP is at an early stage. Several mouse models as well as studies on patient tissues revealed an essential role for CAR in (1) the development of cardiac, renal, lymphatic, and intestinal tissue; (2) muscle pathology, remodeling, and regeneration; (3) tumor genesis/suppression and metastatic progression; and (4) in virus-mediated infections and gene therapy. Although the in vivo function of CAR in the brain has not been solved its developmentally regulated expression pattern in the brain as well as its function as CAM suggests that CAR might be implicated in neuronal network formation." @default.
- W1663640707 created "2016-06-24" @default.
- W1663640707 creator A5033742826 @default.
- W1663640707 creator A5044800358 @default.
- W1663640707 creator A5047729311 @default.
- W1663640707 creator A5075526578 @default.
- W1663640707 date "2013-10-17" @default.
- W1663640707 modified "2023-09-23" @default.
- W1663640707 title "The IgCAMs CAR, BT-IgSF, and CLMP: Structure, Function, and Diseases" @default.
- W1663640707 cites W1240163258 @default.
- W1663640707 cites W1824100774 @default.
- W1663640707 cites W1857650329 @default.
- W1663640707 cites W1932654578 @default.
- W1663640707 cites W1942221917 @default.
- W1663640707 cites W1954119403 @default.
- W1663640707 cites W1963910714 @default.
- W1663640707 cites W1964845139 @default.
- W1663640707 cites W1967939940 @default.
- W1663640707 cites W1974080806 @default.
- W1663640707 cites W1974875111 @default.
- W1663640707 cites W1975364034 @default.
- W1663640707 cites W1979595415 @default.
- W1663640707 cites W1980133890 @default.
- W1663640707 cites W1982082460 @default.
- W1663640707 cites W1983128675 @default.
- W1663640707 cites W1984402213 @default.
- W1663640707 cites W1988876819 @default.
- W1663640707 cites W1989040305 @default.
- W1663640707 cites W1991137546 @default.
- W1663640707 cites W1993492475 @default.
- W1663640707 cites W1997525701 @default.
- W1663640707 cites W1998393175 @default.
- W1663640707 cites W2001070008 @default.
- W1663640707 cites W2004109703 @default.
- W1663640707 cites W2004326366 @default.
- W1663640707 cites W2005127084 @default.
- W1663640707 cites W2006792093 @default.
- W1663640707 cites W2008078589 @default.
- W1663640707 cites W2008708165 @default.
- W1663640707 cites W2009812521 @default.
- W1663640707 cites W2011912615 @default.
- W1663640707 cites W2013599823 @default.
- W1663640707 cites W2013600662 @default.
- W1663640707 cites W2015151811 @default.
- W1663640707 cites W2017550401 @default.
- W1663640707 cites W2017692466 @default.
- W1663640707 cites W2019476355 @default.
- W1663640707 cites W2021854607 @default.
- W1663640707 cites W2023089171 @default.
- W1663640707 cites W2025077054 @default.
- W1663640707 cites W2027213473 @default.
- W1663640707 cites W2027689944 @default.
- W1663640707 cites W2029325021 @default.
- W1663640707 cites W2031066016 @default.
- W1663640707 cites W2031068361 @default.
- W1663640707 cites W2035834158 @default.
- W1663640707 cites W2035947468 @default.
- W1663640707 cites W2036221744 @default.
- W1663640707 cites W2037262542 @default.
- W1663640707 cites W2038648872 @default.
- W1663640707 cites W2041854719 @default.
- W1663640707 cites W2043333187 @default.
- W1663640707 cites W2047724121 @default.
- W1663640707 cites W2047832896 @default.
- W1663640707 cites W2048142299 @default.
- W1663640707 cites W2049018391 @default.
- W1663640707 cites W2050015911 @default.
- W1663640707 cites W2050853446 @default.
- W1663640707 cites W2051758487 @default.
- W1663640707 cites W2051891231 @default.
- W1663640707 cites W2053475427 @default.
- W1663640707 cites W2053697025 @default.
- W1663640707 cites W2055678715 @default.
- W1663640707 cites W2055842243 @default.
- W1663640707 cites W2056891070 @default.
- W1663640707 cites W2058038884 @default.
- W1663640707 cites W2058384876 @default.
- W1663640707 cites W2059510767 @default.
- W1663640707 cites W2060198143 @default.
- W1663640707 cites W2062855335 @default.
- W1663640707 cites W2065392104 @default.
- W1663640707 cites W2065424348 @default.
- W1663640707 cites W2065591885 @default.
- W1663640707 cites W2067488931 @default.
- W1663640707 cites W2068270758 @default.
- W1663640707 cites W2068668309 @default.
- W1663640707 cites W2069513692 @default.
- W1663640707 cites W2072603494 @default.
- W1663640707 cites W2073716939 @default.
- W1663640707 cites W2074741683 @default.
- W1663640707 cites W2076803415 @default.
- W1663640707 cites W2078549990 @default.
- W1663640707 cites W2079050474 @default.
- W1663640707 cites W2079295497 @default.
- W1663640707 cites W2079749916 @default.
- W1663640707 cites W2079954137 @default.
- W1663640707 cites W2082719475 @default.
- W1663640707 cites W2082823773 @default.