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- W1663780585 abstract "Fragile X syndrome, the most common form of inherited mental retardation, is caused by mutations that result in loss of the FMRP protein. As Moine and Mandel explain in their Perspective, FMRP has now been found to bind to G-quartet structures in target mRNAs (many of which encode important neuronal proteins) and, in some cases, to prevent their translation. Absence of FMRP in fragile X patients causes dysregulation of the translation of specific mRNAs, leading to neuronal abnormalities." @default.
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- W1663780585 date "2001-12-21" @default.
- W1663780585 modified "2023-09-26" @default.
- W1663780585 title "Do G Quartets Orchestrate Fragile X Pathology?" @default.
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- W1663780585 doi "https://doi.org/10.1126/science.1068352" @default.
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