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• W1663829637 abstract "Recently, gene therapy vectors based upon the human immunodeficiency virus type 1 (HIV-1) genome have been developed. Here, we create an HIV-1 vector which is defective for all HIV-1 genes, but which maintains cis-acting elements required for efficient packaging, infection, and expression. In T cells transduced by this vector, vector expression is low but efficiently induced following HIV-1 infection. Remarkably, although the HIV-1 vector does not contain specific anti-HIV-1 therapeutic genes, the presence of the vector alone is sufficient to inhibit the spread of HIV-1 infection. The mechanism of inhibition is likely to be at the level of competition for limiting substrates required for either efficient packaging or reverse transcription, thereby selecting against propagation of wild-type HIV-1. These results provide proof of a concept for potential application of a novel HIV-1 vector in HIV-1 disease." @default.
• W1663829637 created "2016-06-24" @default.
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• W1663829637 date "1999-09-01" @default.
• W1663829637 modified "2023-10-17" @default.
• W1663829637 title "An Inducible Human Immunodeficiency Virus Type 1 (HIV-1) Vector Which Effectively Suppresses HIV-1 Replication" @default.
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• W1663829637 doi "https://doi.org/10.1128/jvi.73.9.7671-7677.1999" @default.
• W1663829637 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/104294" @default.
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