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• W1663861494 abstract "Abstract Dendritic cells (DCs) are well known for their capacity to induce adaptive antitumor immune response through Ag presentation and tumor-specific T cell activation. Recent findings reveal that besides this role, DCs may display additional antitumor effects. In this study, we provide evidence that LPS- or IFN-γ-activated rat bone marrow-derived dendritic cells (BMDCs) display killing properties against tumor cells. These cytotoxic BMDCs exhibit a mature DC phenotype, produce high amounts of IL-12, IL-6, and TNF-α, and retain their phagocytic properties. BMDC-mediated tumor cell killing requires cell-cell contact and depends on NO production, but not on perforin/granzyme or on death receptors. Furthermore, dead tumor cells do not exhibit characteristics of apoptosis. Thus, intratumoral LPS injections induce an increase of inducible NO synthase expression in tumor-infiltrating DCs associated with a significant arrest of tumor growth. Altogether, these results suggest that LPS-activated BMDCs represent powerful tumoricidal cells which enforce their potential as anticancer cellular vaccines." @default.
• W1663861494 created "2016-06-24" @default.
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• W1663861494 date "2007-07-15" @default.
• W1663861494 modified "2023-10-05" @default.
• W1663861494 title "Dendritic Cells Trigger Tumor Cell Death by a Nitric Oxide-Dependent Mechanism" @default.
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• W1663861494 doi "https://doi.org/10.4049/jimmunol.179.2.812" @default.
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