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• W1664358915 startingPage "265" @default.
• W1664358915 abstract "The nucleus accumbens (Acb) contains subpopulations of neurons defined by their receptor content and potential involvement in sensorimotor gating and other behaviors that are dysfunctional in schizophrenia. In Acb neurons, the NMDA NR1 (NR1) subunit is coexpressed not only with the dopamine D1 receptor (D1R), but also with the µ-opioid receptor (µ-OR), which mediates certain behaviors that are adversely impacted by schizophrenia. The NMDA-NR1 subunit has been suggested to play a role in the D1R trafficking and behavioral dysfunctions resulting from systemic administration of apomorphine, a D1R and dopamine D2 receptor agonist that impacts prepulse inhibition to auditory-evoked startle (AS). Together, this evidence suggests that the NMDA receptor may regulate D1R trafficking in Acb neurons, including those expressing µ-OR, in animals exposed to auditory startle and apomorphine. We tested this hypothesis by combining spatial-temporal gene deletion technology, dual labeling immunocytochemistry, and behavioral analysis. Deleting NR1 in Acb neurons prevented the increase in the dendritic density of plasma membrane D1Rs in single D1R and dual (D1R and µ-OR) labeled dendrites in the Acb in response to apomorphine and AS. Deleting NR1 also attenuated the decrease in AS induced by apomorphine. In the absence of apomorphine and startle, deletion of Acb NR1 diminished social interaction, without affecting novel object recognition, or open field activity. These results suggest that NR1 expression in the Acb is essential for apomorphine-induced D1R surface trafficking, as well as auditory startle and social behaviors that are impaired in multiple psychiatric disorders." @default.
• W1664358915 created "2016-06-24" @default.
• W1664358915 creator A5000400489 @default.
• W1664358915 creator A5021289576 @default.
• W1664358915 creator A5079818001 @default.
• W1664358915 creator A5072847452 @default.
• W1664358915 date "2013-03-05" @default.
• W1664358915 modified "2023-10-18" @default.
• W1664358915 title "Deletion of the NMDA-NR1 receptor subunit gene in the mouse nucleus accumbens attenuates apomorphine-induced dopamine D1 receptor trafficking and acoustic startle behavior" @default.
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• W1664358915 doi "https://doi.org/10.1002/syn.21637" @default.
• W1664358915 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3894854" @default.
• W1664358915 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23345061" @default.
• W1664358915 hasPublicationYear "2013" @default.
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